Britton K E, Carson E R, Cage P E
Postgrad Med J. 1976 May;52(607):279-84. doi: 10.1136/pgmj.52.607.279.
The ‘bootstrap’ model of the handling of salt, water and urea by the renal medulla is based on the concepts and data of Stephenson (1972), and Kokko and Rector (1972), and adds support to them. Revision of the traditional counter current hypothesis is necessary since active transport of salt and urea is absent from the inner medulla. This advanced model is structured appropriately and demonstrates how events in the medulla interact and vary with time as change from a diuretic to an antidiuretic state proceeds.
肾髓质对盐、水和尿素的处理的“自展”模型基于斯蒂芬森(1972年)以及科科和雷克托(1972年)的概念和数据,并为它们提供了支持。由于内髓质不存在盐和尿素的主动转运,因此有必要对传统的逆流假说进行修正。这个先进的模型结构合理,展示了随着从利尿状态转变为抗利尿状态的过程,髓质中的各种事件是如何相互作用并随时间变化的。