Claveria L E, Calne D B, Allen J G
Br Med J. 1973 Jun 16;2(5867):641-3. doi: 10.1136/bmj.2.5867.641.
The neurological deficit and plasma concentrations of levodopa have been studied in a Parkinsonian patient experiencing "on-off" phenomena. Blind evaluations of transient attacks of dysphonia revealed an association between episodes of neurological deterioration and exceptionally high plasma concentrations of levodopa shortly after ingestion. These results indicate that "on-off" phenomena can be toxic reactions to levodopa rather than deteriorations due to inadequate intake or absorption of the drug. Management of patients subject to such attacks should be aimed at minimizing fluctuations in the serum level of the drug.
对一名出现“开-关”现象的帕金森病患者的神经功能缺损和左旋多巴血浆浓度进行了研究。对短暂性发音障碍发作的盲法评估显示，神经功能恶化发作与摄入后不久血浆中左旋多巴异常高浓度之间存在关联。这些结果表明，“开-关”现象可能是对左旋多巴的毒性反应，而非药物摄入不足或吸收不良导致的病情恶化。对遭受此类发作的患者进行管理应旨在尽量减少药物血清水平的波动。
