用脑外脱羧酶抑制剂与左旋多巴联合治疗特发性帕金森病。
Idiopathic Parkinsonism treated with an extracerebral decarboxylase inhibitor in combination with levodopa.
作者信息
Calne D B, Reid J L, Vakil S D, Rao S, Petrie A, Pallis C A, Gawler J, Thomas P K, Hilson A
出版信息
Br Med J. 1971 Sep 25;3(5777):729-32. doi: 10.1136/bmj.3.5777.729.
Abstract
The clinical actions of levodopa in Parkinsonism, given with and without an extracerebral decarboxylase in hibitor, L-alpha-methyldopahydrazine, were compared. Twenty-one patients were investigated in a "double-blind cross-over" study, administering levodopa in maximum tolerated dosage. L-Alpha-methyldopahydrazine failed to augment the overall therapeutic actions of levodopa but it consistently alleviated nausea. It is concluded that L-alpha-methyldopahydrazine will prove useful in the management of some Parkinsonian patients who have difficulty in taking levodopa alone.
摘要
比较了左旋多巴在帕金森病中的临床作用，分别在加用和未加用脑外脱羧酶抑制剂L-α-甲基多巴肼的情况下进行。在一项“双盲交叉”研究中，对21例患者进行了调查，给予最大耐受剂量的左旋多巴。L-α-甲基多巴肼未能增强左旋多巴的总体治疗作用，但它持续缓解了恶心症状。得出的结论是，L-α-甲基多巴肼将被证明对一些单独服用左旋多巴有困难的帕金森病患者的治疗有用。
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