人体心脏功能的模拟。
A simulation of human heart function.
作者信息
Hanna W T
出版信息
Biophys J. 1973 Jul;13(7):603-21. doi: 10.1016/S0006-3495(73)86011-4.
A simulation of the function of the human heart and heart muscle has been developed in the form of a digital computer code. For a given set of values for the input variables, realistic values of the cardiac output variables are predicted. A detailed discussion of the simulation and some results obtained from its application are presented. This simulation represents a unique combination of what was known in muscle mechanics, muscle thermodynamics, and of the structure, size, and shape of the heart, into an engineering model to improve the understanding of human heart muscle function. The left ventricle (LV) is treated as a thick-walled sphere whose wall is composed entirely of muscle fibers. Force-length velocity relationships are used to determine the tension in each fiber. The pressure in the LV is computed from fiber tension and fiber structure in the LV. A lumped-parameter simulation of the arterial tree provides a load impedance for the LV. Results are presented for simulation of normal human LV performance.
已经以数字计算机代码的形式开发了人体心脏和心肌功能的模拟。对于给定的一组输入变量值，可以预测心输出量变量的实际值。本文对该模拟进行了详细讨论，并给出了从其应用中获得的一些结果。该模拟将肌肉力学、肌肉热力学以及心脏的结构、大小和形状等方面的已知知识独特地结合在一起，形成了一个工程模型，以增进对人体心肌功能的理解。左心室（LV）被视为一个厚壁球体，其壁完全由肌纤维组成。利用力-长度-速度关系来确定每根纤维中的张力。左心室内的压力由左心室内的纤维张力和纤维结构计算得出。动脉树的集总参数模拟为左心室提供了负载阻抗。给出了正常人体左心室性能模拟的结果。
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