羟乙基淀粉的结构。
The structure of hydroxyethyl starch.
作者信息
Banks W, Greenwood C T, Muir D D
出版信息
Br J Pharmacol. 1973 Jan;47(1):172-8. doi: 10.1111/j.1476-5381.1973.tb08171.x.
Abstract
- It is suggested that the structure currently used to describe hydroxyethyl starch (a blood plasma volume expander) is a gross oversimplification.2. A model having a much more complex substitution-pattern is proposed, and an accurate, rapid test has been devised for distinguishing between the two models.3. This test shows that the simple model has no basis in reality, and that the more complex substitution pattern is correct.4. Studies involving the enzymic hydrolysis of hydroxyethyl starch are shown to provide qualitative support for the new model, and the significance of the findings is discussed.
摘要
有人认为，目前用于描述羟乙基淀粉（一种血浆容量扩充剂）的结构过于简单。
提出了一种具有更复杂取代模式的模型，并设计了一种准确、快速的测试方法来区分这两种模型。
该测试表明，简单模型没有现实依据，而更复杂的取代模式是正确的。
涉及羟乙基淀粉酶促水解的研究为新模型提供了定性支持，并讨论了研究结果的意义。
相似文献
1
The structure of hydroxyethyl starch.羟乙基淀粉的结构。
Br J Pharmacol. 1973 Jan;47(1):172-8. doi: 10.1111/j.1476-5381.1973.tb08171.x.
2
Blood volume determination using hydroxyethyl starch: a rapid and simple intravenous injection method.
Crit Care Med. 1997 Apr;25(4):599-606. doi: 10.1097/00003246-199704000-00008.
3
Studies on hydroxyethyl starch as a plasma expander. II. Influences of molecular weight of hydroxyethyl starch on its physicochemical and biological properties.羟乙基淀粉作为血浆代用品的研究。II. 羟乙基淀粉分子量对其理化性质和生物学性质的影响。
Chem Pharm Bull (Tokyo). 1971 Feb;19(2):286-91. doi: 10.1248/cpb.19.286.
4
5
6
[A study on the distribution of hydroxyethyl groups in hydroxyethyl-starch].[羟乙基淀粉中羟乙基基团分布的研究]
Yakugaku Zasshi. 1972 Dec;92(12):1500-6. doi: 10.1248/yakushi1947.92.12_1500.
7
Fluorocarbon-polyol artificial blood substitutes.氟碳-多元醇人工血液替代品
N Engl J Med. 1973 Nov 15;289(20):1077-82. doi: 10.1056/NEJM197311152892008.
8
9
10
[Physico-chemical and biological properties of a new plasma substitute based on hydroxyethylated starch].[基于羟乙基化淀粉的新型血浆代用品的物理化学和生物学特性]
Bioorg Khim. 1986 Jun;12(6):812-8.
引用本文的文献
1
Changes in the degree of substitution of HES in vivo and their influence on methods for determining HES concentrations in plasma.体内 HES 取代度的变化及其对 HES 血浆浓度测定方法的影响。
PLoS One. 2023 Aug 22;18(8):e0290339. doi: 10.1371/journal.pone.0290339. eCollection 2023.
本文引用的文献
1
BLEEDING VOLUME INDICES OF HYDROXYETHYL STARCH, DEXTRAN, BLOOD, AND GLUCOSE.羟乙基淀粉、右旋糖酐、血液和葡萄糖的出血量指标。
Proc Soc Exp Biol Med. 1964 Feb;115:474-7. doi: 10.3181/00379727-115-28945.
2
Hypotension and histamine release following intravenous injection of plasma substitutes.静脉注射血浆代用品后的低血压和组胺释放。
J Pharmacol Exp Ther. 1959 Sep;127:39-45.
3
An investigation of oxyethylstarch as a new plasma volume expander in animals.对羟乙基淀粉作为一种新型血浆容量扩充剂在动物体内的研究。
Arch Int Pharmacodyn Ther. 1957 Aug 1;111(3):353-61.
4
An evaluation of infusion therapy (including dextran) for venous thrombosis.静脉血栓形成的输液治疗（包括右旋糖酐）评估。
Circulation. 1966 Jun;33(6):839-46. doi: 10.1161/01.cir.33.6.839.
5
The alpha-amylase from broad beans. Purification and properties.蚕豆中的α-淀粉酶。纯化及性质
Arch Biochem Biophys. 1965 Dec;112(3):459-65. doi: 10.1016/0003-9861(65)90080-9.
6
Intravascular persistence, tissue storage, and excretion of hydroxyethyl starch.羟乙基淀粉的血管内留存、组织储存及排泄
Surg Gynecol Obstet. 1970 Nov;131(5):965-72.
Zotero 插件