自身免疫性溶血性贫血。VI. 51 不同类型温抗体患者的铬存活研究。
Autoimmune haemolytic anaemia. VI. 51 Chromium survival studies in patients with different kinds of warm autoantibodies.
作者信息
Engelfriet C P, Reynierse E, Beckers D, van Loghem J J
出版信息
Clin Exp Immunol. 1973 Apr;13(4):561-71.
The results of Cr red cell survival and organ sequestration studies in seventysix patients with autoimmune haemolytic anaemia are described. In patients with incomplete IgG and IgA warm autoantibodies increased red cell destruction to a varying degree and mainly spleen sequestration were found. In patients with IgM incomplete warm autoantibodies sequestration of red cells mainly in the liver was seen. Liver sequestration was also present in patients with cold agglutinins/haemolysis, sometimes accompanied by a significant spleen sequestration. In a number of patients with haemolytic autoantibodies, i.e. warm haemolysins and cold agglutinins/haemolysins, a biphasic Cr elimination curve was obtained. The cause of this type of survival curve is discussed. In patients in whom a positive direct anticomplement test was the only serological abnormality a normal Cr red cell life-span was found.
本文描述了76例自身免疫性溶血性贫血患者的铬红细胞存活及器官扣押研究结果。在伴有不完全IgG和IgA温抗体的患者中，发现红细胞破坏程度各异，主要为脾脏扣押。在伴有IgM不完全温抗体的患者中，可见红细胞主要扣押于肝脏。冷凝集素/溶血患者也存在肝脏扣押，有时伴有显著的脾脏扣押。在一些伴有溶血性自身抗体（即温溶血素和冷凝集素/溶血素）的患者中，获得了双相铬清除曲线。本文讨论了这种存活曲线类型的原因。在直接抗补体试验阳性为唯一血清学异常的患者中，发现铬红细胞寿命正常。
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