不同去极化药物产生的“终板噪声”的特征。
The characteristics of 'end-plate noise' produced by different depolarizing drugs.
作者信息
Katz B, Miledi R
出版信息
J Physiol. 1973 May;230(3):707-17. doi: 10.1113/jphysiol.1973.sp010213.
Abstract
- End-plate depolarization and associated ;membrane noise' due to decamethonium, acetylthiocholine and suberyldicholine have been examined and compared with the effects of acetylcholine and carbachol.2. The transient ionic channels resulting from the action of decamethonium and acetylthiocholine are of much shorter duration than those produced by acetylcholine. They are, therefore, similarly to carbachol channels, less effective in causing membrane depolarization.3. Suberyldicholine, on the other hand, produces ion channels whose duration exceeds that of acetylcholine.4. Lowering the temperature causes an increase in amplitude of the elementary potential change produced by decamethonium and acetylthiocholine.5. The relation between the characteristic features of drug-induced membrane noise and the underlying molecular reaction rates is discussed.
摘要
已对十烃季铵、乙酰硫代胆碱和辛二酰二胆碱引起的终板去极化及相关“膜噪声”进行了研究，并与乙酰胆碱和卡巴胆碱的作用进行了比较。
由十烃季铵和乙酰硫代胆碱作用产生的瞬时离子通道持续时间比乙酰胆碱产生的要短得多。因此，它们与卡巴胆碱通道类似，在引起膜去极化方面效果较差。
另一方面，辛二酰二胆碱产生的离子通道持续时间超过乙酰胆碱。
降低温度会导致十烃季铵和乙酰硫代胆碱产生的基本电位变化幅度增加。
讨论了药物诱导的膜噪声的特征与潜在分子反应速率之间的关系。
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本文引用的文献
1
Failure of neuromuscular propagation in rats.大鼠神经肌肉传导障碍
J Physiol. 1958 Mar 11;140(3):440-61.
2
Interaction at end-plate receptors between different choline derivatives.不同胆碱衍生物在终板受体处的相互作用。
Proc R Soc Lond B Biol Sci. 1957 May 7;146(924):369-81. doi: 10.1098/rspb.1957.0018.
3
A comparison of acetylcholine and stable depolarizing agents.乙酰胆碱与稳定去极化剂的比较。
Proc R Soc Lond B Biol Sci. 1957 May 7;146(924):362-8. doi: 10.1098/rspb.1957.0017.
4
An investigation of spontaneous activity at the neuromuscular junction of the rat.大鼠神经肌肉接头处自发活动的研究。
J Physiol. 1956 Jun 28;132(3):650-66. doi: 10.1113/jphysiol.1956.sp005555.
5
Structure of acetylcholine and other substrates of cholinergic systems.
Nature. 1966 May 28;210(5039):907-9. doi: 10.1038/210907a0.
6
[On the mechanism of desensitization of the muscle fiber postsynaptic membrane].[关于肌纤维突触后膜脱敏的机制]
Biofizika. 1968 Jan-Feb;13(1):199-203.
7
Conformation of some acetylcholine analogs as solutes in deuterium oxide and other solvents.
J Pharm Sci. 1971 Jan;60(1):67-73. doi: 10.1002/jps.2600600112.
8
Membrane noise produced by acetylcholine.乙酰胆碱产生的膜噪声。
Nature. 1970 Jun 6;226(5249):962-3. doi: 10.1038/226962a0.
9
10
The statistical nature of the acetycholine potential and its molecular components.乙酰胆碱电位及其分子成分的统计学性质。
J Physiol. 1972 Aug;224(3):665-99. doi: 10.1113/jphysiol.1972.sp009918.
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