Gray P T, Rang H P
Br J Pharmacol. 1983 Oct;80(2):235-40. doi: 10.1111/j.1476-5381.1983.tb10025.x.
The kinetics of the responses of rat submandibular ganglion neurones to nicotinic agonists were investigated by the analysis of agonist-induced membrane current noise. Two kinetic components are found in the responses of these cells to acetylcholine, carbachol, suberyldicholine, dimethyl-4-phenylpiperazinium and nicotine, in agreement with previous findings of two components in evoked synaptic currents in these cells. Small, though significant, differences in the relative amplitudes of the two kinetic components were observed in the spectra of noise evoked by the different agonists. In particular, the fast component in the response to carbachol was relatively larger with respect to the slow component than with any other agonist tested. No measurable dependence of the relative sizes of the two components on agonist concentration or membrane potential was observed. The evidence supports the hypothesis that the two kinetic components are the product of two independent channel populations for which the agonists tested show some slight differences in selectivity.
通过分析激动剂诱导的膜电流噪声，研究了大鼠下颌下神经节神经元对烟碱激动剂的反应动力学。这些细胞对乙酰胆碱、卡巴胆碱、辛二酰胆碱、二甲基-4-苯基哌嗪鎓和尼古丁的反应中发现了两个动力学成分，这与之前在这些细胞中诱发的突触电流中发现的两个成分一致。在不同激动剂诱发的噪声谱中，观察到两个动力学成分的相对幅度存在微小但显著的差异。特别是，与其他测试的激动剂相比，卡巴胆碱反应中的快速成分相对于慢速成分相对更大。未观察到两个成分的相对大小对激动剂浓度或膜电位有可测量的依赖性。证据支持这样的假设，即这两个动力学成分是两个独立通道群体的产物，所测试的激动剂对它们的选择性存在一些细微差异。
