苯二氮䓬类药物和三环类抗抑郁药的血浆水平。
Benzodiazepines and tricyclic antidepressant plasma levels.
作者信息
Silverman G, Braithwaite R A
出版信息
Br Med J. 1973 Jul 7;3(5870):18-20. doi: 10.1136/bmj.3.5870.18.
Abstract
Twelve patients acted successfully as subjects to study what effect if any the benzodiazepines nitrazepam, diazepam, oxazepam, and chlordiazepoxide might have on steady-state plasma levels of nortriptyline and amitriptyline. No significant detectable effect was discovered. In view of the known interaction effects of other alternative tranquillizing drugs and hypnotics it seems reasonable to choose benzodiazepines wherever possible when anxiolytics or hypnotics need to be added during treatment of depression with tricyclic antidepressants.
摘要
12名患者成功作为研究对象，以探究苯二氮䓬类药物硝西泮、地西泮、奥沙西泮和氯氮䓬对去甲替林和阿米替林稳态血浆水平可能产生的影响（若有影响的话）。未发现明显可检测到的影响。鉴于其他替代镇静药物和催眠药已知的相互作用效应，在三环类抗抑郁药治疗抑郁症期间需要添加抗焦虑药或催眠药时，尽可能选择苯二氮䓬类药物似乎是合理的。
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本文引用的文献
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