苯二氮䓬类药物与华法林的相互作用。
Interactions of benzodiazepines with warfarin.
作者信息
Orme M, Breckenridge A, Brooks R V
出版信息
Br Med J. 1972 Sep 9;3(5827):611-4. doi: 10.1136/bmj.3.5827.611.
Abstract
Administration of nitrazepam (10 mg nightly), diazepam (15 mg/day), and chlordiazepoxide (15 and 30 mg/day) had no effect on steady-state plasma warfarin concentrations, the plasma half-life of warfarin, or anticoagulant control in patients and it appears safe to prescribe these agents to patients on long-term oral anticoagulants. Urinary excretion of 6 beta-hydroxycortisol, however, increased in two out of five patients given chlordiazepoxide. In rats pretreatment with chlordiazepoxide (40 mg/kg for four days) caused stimulation of liver microsomal enzyme activity but neither diazepam nor nitrazepam had this effect.
摘要
服用硝西泮（每晚10毫克）、地西泮（每日15毫克）和氯氮卓（每日15毫克和30毫克）对患者的华法林稳态血浆浓度、华法林的血浆半衰期或抗凝控制均无影响，因此给长期口服抗凝剂的患者开这些药物似乎是安全的。然而，在五名服用氯氮卓的患者中，有两名患者的6β-羟基皮质醇尿排泄量增加。在大鼠中，氯氮卓预处理（40毫克/千克，持续四天）可刺激肝脏微粒体酶活性，但地西泮和硝西泮均无此作用。
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