Baglin A, Goupil A, Domart M, Fritel D
Nouv Presse Med. 1979 May 19;8(22):1821-5.
The effects of dopamine on renal excretory function were studied in 20 patients with chronic renal failure (plasma creatinine higher than 30 mg/i). Effects were marked at a dose of 2 micrograms/kg/mn and were no greater at a dose of 5 micrograms/kg/mn (10 subjects in each case). In general, creatinine clearance increased by 28%, urea excretion by 45%, urine output by 77% and urinary sodium output by 164%. In ten patiens with terminal renal failure (plasma creatinine greater than 100 mg/i), the effects of dopamine were maintained. In these individuals, furosemide (250 mg by single intravenous injection) resulted in a higher total urine and urinary sodium output but had a less favourable effect upon creatinine.
对20例慢性肾衰竭患者（血浆肌酐高于30mg/1）研究了多巴胺对肾脏排泄功能的影响。剂量为2微克/千克/分钟时效果显著，剂量为5微克/千克/分钟时效果并未增强（每组各10名受试者）。一般来说，肌酐清除率提高了28%，尿素排泄量提高了45%，尿量提高了77%，尿钠排泄量提高了164%。在10例终末期肾衰竭患者（血浆肌酐大于100mg/1）中，多巴胺的作用持续存在。对这些患者，速尿（单次静脉注射250mg）使总尿量和尿钠排泄量更高，但对肌酐的影响较差。
