Pozet N, Zech P, Pellet M, Traeger J
Nouv Presse Med. 1975 Dec 31;4(46 Suppl):3252-5.
A study was carried out, of the changes of renal functional value and of urinary electrolytes excretion after rapid intravenous injection of acebutolol in twelve subjects with various glomerular filtration. Renal functional value was estimated by measuring inuline. P.A.H., urea and creatinin clearances during a control period of thirty minutes and during the four hours following administration of acebutolol. The variations in the excretion of electrolytes: chloride, sodium, potassium, calcium and phosphorus were measured during the same periods. The following results were obtained: in subjects with normal renal functional value, administration of acetubolol brings about: a variation which is under 20 p.cent of glomerular filtration and P.A.H. clearance; a 50 p.cent average decrease of natriuresis. in cases of renal insufficiency: clearances of inuline and P.A.H. are unchanged. There is a 20 p.cent average decrease of natriuresis. There is a decrease of urinary output (35-45 p.cent) and of urea clearance (20-50 p.cent).
对12名具有不同肾小球滤过率的受试者快速静脉注射醋丁洛尔后，进行了肾功能值及尿电解质排泄变化的研究。通过在30分钟的对照期以及醋丁洛尔给药后的4小时内测量菊粉、对氨基马尿酸（P.A.H.）、尿素和肌酐清除率来评估肾功能值。在同一时期测量电解质（氯、钠、钾、钙和磷）排泄的变化。得到以下结果：在肾功能值正常的受试者中，给予醋丁洛尔会导致：肾小球滤过率和P.A.H.清除率变化低于20%；利钠平均降低50%。在肾功能不全的情况下：菊粉和P.A.H.清除率不变。利钠平均降低20%。尿量减少（35 - 45%），尿素清除率降低（20 - 50%）。
