儿茶酚-O-甲基转移酶。4. 3-羟基-4-吡喃酮、3-羟基-2-吡啶酮和3-羟基-4-吡啶酮的体外抑制作用。 - Suppr

Suppr

超能文献

Catechol O-methyltransferase. 4. In vitro inhibition by 3-hydroxy-4-pyrones, 3-hydroxy-2-pyridones, and 3-hydroxy-4-pyridones.

作者信息

Borchardt R T

出版信息

J Med Chem. 1973 May;16(5):581-3. doi: 10.1021/jm00263a047.

DOI:10.1021/jm00263a047

PMID:4718481

Abstract

摘要

相似文献

Catechol O-methyltransferase. 4. In vitro inhibition by 3-hydroxy-4-pyrones, 3-hydroxy-2-pyridones, and 3-hydroxy-4-pyridones.儿茶酚-O-甲基转移酶。4. 3-羟基-4-吡喃酮、3-羟基-2-吡啶酮和3-羟基-4-吡啶酮的体外抑制作用。

J Med Chem. 1973 May;16(5):581-3. doi: 10.1021/jm00263a047.

Catechol O-methyltransferase. 1. Kinetics of tropolone inhibition.

J Med Chem. 1973 Apr;16(4):377-82. doi: 10.1021/jm00262a015.

Inhibition of catechol-O-methyltransferase by S-adenosylhomocysteine and S-adenosylhomocysteine sulfoxide, a potential transition-state analog.S-腺苷同型半胱氨酸和S-腺苷同型半胱氨酸亚砜对儿茶酚-O-甲基转移酶的抑制作用，一种潜在的过渡态类似物。

Biochem Pharmacol. 1972 Apr 15;21(8):1200-3. doi: 10.1016/0006-2952(72)90114-1.

Catechol O-methyltransferase. 2. In vitro inhibition by substituted 8-hydroxyquinolines.

J Med Chem. 1973 Apr;16(4):382-7. doi: 10.1021/jm00262a016.

Inhibition of human liver catechol-O-methyltransferase by flavonoids.

Naunyn Schmiedebergs Arch Pharmacol. 1973;276(2):223-33. doi: 10.1007/BF00501194.

Evidence for the methylation of apomorphine by catechol-O-methyl-transferase in vivo and in vitro.

Biochem Pharmacol. 1973 Sep 15;22(18):2329-36. doi: 10.1016/0006-2952(73)90014-2.

Catechol O-methyltransferase. 3. Mechanism of pyridoxal 5'-phosphate inhibition.

J Med Chem. 1973 Apr;16(4):387-91. doi: 10.1021/jm00262a017.

The in vivo effect of tropolone on dopamine metabolism and the catechol-O-methyl transferase activity in the striatum of the rat.原儿茶酸对大鼠纹状体中多巴胺代谢及儿茶酚-O-甲基转移酶活性的体内效应。

Acta Pharmacol Toxicol (Copenh). 1972;31(3):217-25. doi: 10.1111/j.1600-0773.1972.tb00716.x.

The in vivo effect of tropolone on noradrenaline metabolism and catechol-O-methyl transferase activity in tissues of the rat.

Acta Pharmacol Toxicol (Copenh). 1973;33(5):417-28. doi: 10.1111/j.1600-0773.1973.tb01543.x.

Synthesis and optimization of N-heterocyclic pyridinones as catechol-O-methyltransferase (COMT) inhibitors.作为儿茶酚-O-甲基转移酶（COMT）抑制剂的N-杂环吡啶酮的合成与优化

Bioorg Med Chem Lett. 2016 Jun 15;26(12):2952-2956. doi: 10.1016/j.bmcl.2016.03.095. Epub 2016 Apr 7.

引用本文的文献

Hydroxypyrone derivatives in drug discovery: from chelation therapy to rational design of metalloenzyme inhibitors.药物研发中的羟基吡喃酮衍生物：从螯合疗法到金属酶抑制剂的合理设计

RSC Med Chem. 2022 Jul 29;13(10):1127-1149. doi: 10.1039/d2md00175f. eCollection 2022 Oct 19.

Design, synthesis and evaluation of 3-hydroxypyridin-4-ones as inhibitors of catechol-O-methyltransferase.设计、合成和评价 3-羟基吡啶-4-酮类化合物作为儿茶酚-O-甲基转移酶抑制剂。

Mol Divers. 2021 May;25(2):753-762. doi: 10.1007/s11030-020-10053-x. Epub 2020 Feb 27.

Synthesis and Evaluation of Heterocyclic Catechol Mimics as Inhibitors of Catechol-O-methyltransferase (COMT).作为儿茶酚-O-甲基转移酶（COMT）抑制剂的杂环儿茶酚类似物的合成与评价

ACS Med Chem Lett. 2015 Jan 26;6(3):318-23. doi: 10.1021/ml500502d. eCollection 2015 Mar 12.

Chronic active hepatitis in mice induced by 3-hydroxy-4-pyrone.

Experientia. 1984 Aug 15;40(8):894-6. doi: 10.1007/BF01952014.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验