3-羟基-4-吡喃酮诱导的小鼠慢性活动性肝炎
Chronic active hepatitis in mice induced by 3-hydroxy-4-pyrone.
作者信息
Bhathal P S, Ho S L, Hegarty M P, Harris R L
出版信息
Experientia. 1984 Aug 15;40(8):894-6. doi: 10.1007/BF01952014.
PMID:6468611
Abstract
Chronic active hepatitis was selectively induced in mice by the feeding of a diet containing 3-hydroxy-4-pyrone (0.5% by weight) for periods of 6 weeks and longer. This model should be of particular value in elucidating the pathogenesis of drug-induced forms of chronic active hepatitis. Maltol (3-hydroxy-2-methyl-4-pyrone) did not produce any liver lesion.
摘要
通过给小鼠喂食含3-羟基-4-吡喃酮（按重量计0.5%）的饲料6周及更长时间，选择性诱导小鼠发生慢性活动性肝炎。该模型在阐明药物诱导型慢性活动性肝炎的发病机制方面应具有特殊价值。麦芽酚（3-羟基-2-甲基-4-吡喃酮）未产生任何肝脏病变。
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