Le Tallec Y, Seguela J P, Duffaut M, Gaillemin C, Arlet P, Bilfeld-Partouche R
Poumon Coeur. 1979;35(2):105-9.
Mucormycoses are rare, acute infections, most often fatal, occurring usually in a host with decreased immunity. The agents are ubiquitous fungi belonging to the Mucoraceae family, an ordinary saprophyte becoming pathogenous in patients with a severe disease (malignant hemopathy, diabetes) or treated by immunosuppressive drugs. Pulmonary localizations remained exceptional (128 cases found in the literature). The observations reported draws its originality from: -- the etiological circumstances: an aged patient with no hemopathy or diabetes, without immunosuppressive treatment but undergoing a prolonged antibiotic therapy; -- the clinical signs: discovery on X-ray of excavated infiltrates in a background of a severe infection with a very poor physical condition; -- the diagnosis criteria with the demonstration of the responsible mucor in the sputum, the endobronchial aspiration and transparietal puncture; -- the great efficiency of Amphotericin B at rather small doses. A review of the literature underlines the exceptional character of the cure.
毛霉病是一种罕见的急性感染,通常致命,多见于免疫力下降的宿主。病原体是属于毛霉科的无处不在的真菌,这种普通的腐生菌在患有严重疾病(恶性血液病、糖尿病)或接受免疫抑制药物治疗的患者中会致病。肺部感染情况仍然罕见(文献中发现128例)。所报告的病例具有以下独特之处:——病因情况:一名老年患者,无血液病或糖尿病,未接受免疫抑制治疗,但正在接受长期抗生素治疗;——临床体征:在严重感染且身体状况极差的背景下,X线检查发现有空洞性浸润;——诊断标准:在痰液、支气管内吸出物和经皮穿刺物中发现致病毛霉;——小剂量两性霉素B具有高效性。文献综述强调了治愈的罕见性。