Li Jordan Y Z, Yong Tuck Y, Jurisevic Craig A, Russ Graeme R, Grove David I, Coates P Toby H, Disney Alex P S
Department of Nephrology and Transplantation Services, The Queen Elizabeth Hospital, Adelaide, South Australia, Australia.
Heart Lung Circ. 2009 Jun;18(3):226-8. doi: 10.1016/j.hlc.2007.12.003. Epub 2008 Mar 4.
Mucormycosis is a rare opportunistic fungal infection in renal transplant recipients which is associated with exceedingly high mortality when inadequately treated. Risk factors for this infection include diabetes, neutropaenia and immunosuppression. We report a case of pulmonary mucormycosis in a renal allograft recipient with type 2 diabetes and limited pulmonary reserve. The patient was successfully treated with lobectomy and liposomal amphotericin B with preservation of pulmonary and allograft functions. Early recognition of this infection is warranted before dissemination, which carries a poor prognosis.
毛霉菌病是肾移植受者中一种罕见的机会性真菌感染，若治疗不当，死亡率极高。这种感染的危险因素包括糖尿病、中性粒细胞减少症和免疫抑制。我们报告一例患有2型糖尿病且肺储备功能有限的肾移植受者发生肺毛霉菌病的病例。该患者通过肺叶切除术和脂质体两性霉素B成功治愈，肺功能和移植肾功能均得以保留。在感染播散之前进行早期识别很有必要，因为播散后的预后很差。
