胰高血糖素对血清胃泌素的影响。II. 恶性贫血和佐林格-埃利森综合征的研究。
Effect of glucagon on serum gastrin. II. Studies in pernicious anaemia and the Zollinger-Ellison syndrome.
作者信息
Korman M G, Soveny C, Hansky J
出版信息
Gut. 1973 Jun;14(6):459-61. doi: 10.1136/gut.14.6.459.
Abstract
Serum gastrin was measured by radioimmunoassay in four patients with pernicious anaemia and four patients with the Zollinger-Ellison syndrome before and after the intravenous injection of 1 mg glucagon. Serum gastrin fell significantly in the patients with pernicious anaemia whilst in the patients with the Zollinger-Ellison syndrome there was a significant rise. Concomitant measurement of gastric acid output in one subject with the Zollinger-Ellison syndrome also showed a rise in acid output with glucagon. The reason for the paradoxical rise in gastrin in response to glucagon in the Zollinger-Ellison syndrome is unknown, but the response may provide a further diagnostic aid to this condition.
摘要
采用放射免疫分析法测定了4例恶性贫血患者和4例佐林格 - 埃利森综合征患者静脉注射1毫克胰高血糖素前后的血清胃泌素水平。恶性贫血患者的血清胃泌素显著下降，而佐林格 - 埃利森综合征患者的血清胃泌素则显著升高。对1例佐林格 - 埃利森综合征患者同时测定胃酸分泌量，结果显示注射胰高血糖素后胃酸分泌量增加。佐林格 - 埃利森综合征患者对胰高血糖素产生胃泌素反常升高的原因尚不清楚，但这种反应可能为该病症提供进一步的诊断依据。
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