胰高血糖素对血清胃泌素的影响。I. 对正常受试者的研究。
The effect of glucagon on serum gastrin. I. Studies in normal subjects.
作者信息
Hansky J, Soveny C, Korman M G
出版信息
Gut. 1973 Jun;14(6):457-61. doi: 10.1136/gut.14.6.457.
Abstract
Serum gastrin has been determined by radioimmunoassay in 13 subjects free of gastrointestinal disease, in the basal state, and following the intravenous injection of 1 mg glucagon. Serum gastrin fell from a mean +/- SEM level of 50.3 +/- 6.7 to 9.4 +/- 3.3 pg/ml at 30 minutes after injection, significant at p<0.005. This is similar to the response previously reported for secretin and indicates a role for glucagon in the control of gastrin release.
摘要
通过放射免疫分析法测定了13名无胃肠道疾病受试者在基础状态下以及静脉注射1毫克胰高血糖素后的血清胃泌素水平。注射后30分钟，血清胃泌素水平从平均±标准误50.3±6.7皮克/毫升降至9.4±3.3皮克/毫升，p<0.005，差异有统计学意义。这与先前报道的促胰液素反应相似，表明胰高血糖素在胃泌素释放的控制中起作用。
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