White R P, Hagen A, Robertson J T
J Neurosurg. 1976 Jan;44(1):45-9. doi: 10.3171/jns.1976.44.1.0045.
Arteriograms of the basilar artery reveal that dopamine given intracisternally to dogs can generate cerebral vasospasm. This finding supports a recent hypothesis of others that dopamine may play a role in the pathogenesis of vasospasm, especially since many substances are known which fail to produce such spasm. Compared to blood or prostaglandin E2, however, the spasm induced by dopamine was delayed in onset, less in incidence, and usually less intense. Possible explanations for such experimental differences are discussed.
基底动脉血管造影显示，给狗脑池内注射多巴胺可引发脑血管痉挛。这一发现支持了其他人最近提出的一种假说，即多巴胺可能在血管痉挛的发病机制中起作用，特别是因为已知许多物质不会产生这种痉挛。然而，与血液或前列腺素E2相比，多巴胺诱发的痉挛发作延迟，发生率较低，且通常强度较小。文中讨论了造成这种实验差异的可能原因。
