Tanaka Y, Frank H, DeLuca H F
Science. 1973 Aug 10;181(4099):564-6. doi: 10.1126/science.181.4099.564.
Rats maintained on a low phosphorus diet supplemented with 25-hydroxyvitamin D(3) show high intestinal calcium transport activity as compared to rats similarly treated but fed a diet containing adequate phosphorus. This increased transport activity is correlated with an increased biosynthesis of 1,25-dihydroxyvitamin D(3), the probable metabolically active form of the vitamin in the intestine.
与同样接受25-羟基维生素D(3)补充但喂食含充足磷饮食的大鼠相比,维持低磷饮食并补充25-羟基维生素D(3)的大鼠肠道钙转运活性较高。这种增加的转运活性与1,25-二羟基维生素D(3)生物合成增加相关,1,25-二羟基维生素D(3)可能是该维生素在肠道中的代谢活性形式。