1,25 - 二羟胆钙化醇治疗对维生素D缺乏大鼠1,25 - 二羟胆钙化醇代谢的刺激作用。
The stimulation of 1,25-dihydroxycholecalciferol metabolism in vitamin D-deficient rats by 1,25-dihydroxycholecalciferol treatment.
作者信息
Frolik C A, DeLuca H F
出版信息
J Clin Invest. 1973 Mar;52(3):543-8. doi: 10.1172/JCI107214.
Abstract
Daily oral administration of 1,25-dihydroxycholecalciferol to vitamin D-deficient rats increases the rate of disappearance of [(3)H]1,25-dihydroxycholecalciferol and increases the rate of appearance of metabolites both less polar and more polar than 1,25-dihydroxycholecalciferol in the intestine, bone, liver, kidney, plasma, and muscle. Since 1,25-dihydroxycholecalciferol is believed to be the metabolically active form of vitamin D in the stimulation of intestinal calcium transport and bone calcium mobilization, these results provide an explanation for the fact that daily oral administration of 1,25-dihydroxycholecalciferol is relatively ineffective in the maintenance of serum calcium and in the calcification of bone in rats.
摘要
每日给维生素D缺乏的大鼠口服1,25 - 二羟胆钙化醇，会增加[(3)H]1,25 - 二羟胆钙化醇在肠道、骨骼、肝脏、肾脏、血浆和肌肉中的消失速率，并增加比1,25 - 二羟胆钙化醇极性更小和更大的代谢产物的出现速率。由于1,25 - 二羟胆钙化醇被认为是维生素D在刺激肠道钙转运和骨钙动员方面具有代谢活性的形式，这些结果解释了以下事实：每日给大鼠口服1,25 - 二羟胆钙化醇在维持血清钙水平和促进大鼠骨骼钙化方面相对无效。
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本文引用的文献
1
Biologically active metabolite of vitamin D3 from bone, liver, and blood serum.来自骨骼、肝脏和血清的维生素D3的生物活性代谢物。
J Lipid Res. 1966 Nov;7(6):739-44.
2
The association of a metabolite of vitamin D3 with intestinal mucosa chromatin in vivo.维生素D3的一种代谢产物与体内肠黏膜染色质的关联。
J Biol Chem. 1968 Aug 10;243(15):4055-64.
3
Role of 1,25-dihydroxycholecalciferol in calcification of bone and maintenance of serum calcium concentration in the rat.1,25-二羟胆钙化醇在大鼠骨骼钙化及血清钙浓度维持中的作用
J Nutr. 1972 Dec;102(12):1569-77. doi: 10.1093/jn/102.12.1569.
4
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J Clin Invest. 1972 Nov;51(11):2900-6. doi: 10.1172/JCI107114.
5
1,25-dihydroxycholecalciferol: metabolite of vitamin D3 active on bone in anephric rats.1,25-二羟胆钙化醇：维生素D3的代谢产物，对无肾大鼠的骨骼有活性作用。
Science. 1972 Jun 9;176(4039):1146-7. doi: 10.1126/science.176.4039.1146.
6
1,25-dihydroxycholecalciferol: a potent stimulator of bone resorption in tissue culture.1,25-二羟胆钙化醇：组织培养中骨吸收的强效刺激剂。
Science. 1972 Feb 18;175(4023):768-9. doi: 10.1126/science.175.4023.768.
7
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