• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

N.3, (SCN).-2和·OH自由基使核糖核酸酶A失活过程中的氧效应对比

Contrasting oxygen-effects in the inactivation of ribonuclease A by N.3, (SCN).-2 and .OH radicals.

作者信息

Prütz W A

出版信息

Radiat Environ Biophys. 1979 Feb 23;16(1):43-8. doi: 10.1007/BF01326895.

DOI:10.1007/BF01326895
PMID:472108
Abstract

N.3 exhibits higher efficiency than .OH in the inactivation of RNase in de-acerated (neutral) aqueous solution. In O2-saturated solution the .OH-induced inactivation is enhanced, but N.3 and (SCN).-2 become remarkably inefficient. Our results suggest that semi-oxidized tyrosine, the predominant initial defect induced by N.3 and (SCN).-2 but not by .OH2 can be re-reduced upon reaction with O.-2 or cysteine.

摘要

在去离子（中性）水溶液中使核糖核酸酶失活时，N.3比·OH表现出更高的效率。在氧气饱和溶液中，·OH诱导的失活作用增强，但N.3和(SCN).-2的效率则显著降低。我们的结果表明，半氧化酪氨酸是由N.3和(SCN).-2而非·OH2诱导产生的主要初始缺陷，它在与O.-2或半胱氨酸反应后可被再次还原。

相似文献

1
Contrasting oxygen-effects in the inactivation of ribonuclease A by N.3, (SCN).-2 and .OH radicals.N.3, (SCN).-2和·OH自由基使核糖核酸酶A失活过程中的氧效应对比
Radiat Environ Biophys. 1979 Feb 23;16(1):43-8. doi: 10.1007/BF01326895.
2
Characterization of secondary radical reactions in irradiated ribonuclease.
Radiat Res. 1975 Jan;61(1):63-79.
3
Free radical reactions with proteins and enzymes: the inactivation of pepsin.蛋白质和酶的自由基反应：胃蛋白酶的失活
Int J Radiat Biol Relat Stud Phys Chem Med. 1979 Jun;35(6):497-507. doi: 10.1080/09553007914550611.
4
Free radical inactivation of lactate dehydrogenase.乳酸脱氢酶的自由基失活作用
Int J Radiat Biol Relat Stud Phys Chem Med. 1976 Aug;30(2):115-27. doi: 10.1080/09553007614550881.
5
Reaction of ethanol radicals with ribonuclease.
Int J Radiat Biol Relat Stud Phys Chem Med. 1976 Nov;30(5):467-72. doi: 10.1080/09553007614551281.
6
The oxidation of ferrocytochrome c by Br2-, (SCN)2-, N3 and OH radicals studied by pulsed-electron and gamma-ray radiolysis.通过脉冲电子和γ射线辐解研究Br2-、(SCN)2-、N3和OH自由基对亚铁细胞色素c的氧化作用。
Biochim Biophys Acta. 1981 Mar 12;635(1):81-9. doi: 10.1016/0005-2728(81)90009-8.
7
The radiation-induced inactivation of external yeast invertase in dilute aqueous solution.稀水溶液中辐射诱导的外源酵母转化酶失活
Int J Radiat Biol. 1989 Feb;55(2):191-200. doi: 10.1080/09553008914550241.
8
Effect of ethanol on the radiolysis of ribonuclease.乙醇对核糖核酸酶辐射分解的影响。
Int J Radiat Biol Relat Stud Phys Chem Med. 1975 Feb;27(2):171-80. doi: 10.1080/09553007514550171.
9
Fast consecutive radical processes within the ribonuclease molecule in aqueous solution. II. Reaction with OH radicals and hydrated electrons.
Biochim Biophys Acta. 1972 Jul 13;276(1):124-42. doi: 10.1016/0005-2744(72)90014-9.
10
Radiation-induced inactivation of dihydroorotate dehydrogenase in dilute aqueous solution.辐射诱导的稀水溶液中二氢乳清酸脱氢酶的失活
Radiat Res. 1992 Oct;132(1):7-12.

本文引用的文献

1
On the mechanism of the radiation-induced inactivation of ribonuclease in dilute aqueous solution.关于稀水溶液中辐射诱导核糖核酸酶失活的机制
Int J Radiat Biol Relat Stud Phys Chem Med. 1971;20(5):405-15. doi: 10.1080/09553007114551311.
2
The radiolysis of dilute solutions of lysozyme. II. Pulse radiolysis studies with cysteine and oxygen.
Int J Radiat Biol Relat Stud Phys Chem Med. 1968 Aug 29;14(1):19-27. doi: 10.1080/09553006814550741.
3
Selective free radical reactions with proteins and enzymes: the inactivation of ribonuclease.
Radiat Res. 1972 Feb;49(2):290-9.
4
Selective free radical reactions with proteins and enzymes: reactions of inorganic radical anions with amino acids.蛋白质和酶的选择性自由基反应：无机自由基阴离子与氨基酸的反应。
Radiat Res. 1972 Feb;49(2):278-89.
5
Fast consecutive radical processes within the ribonuclease molecule in aqueous solution. II. Reaction with OH radicals and hydrated electrons.
Biochim Biophys Acta. 1972 Jul 13;276(1):124-42. doi: 10.1016/0005-2744(72)90014-9.
6
Inactivation of ribonuclease by the primary aqueous radicals.核糖核酸酶被初级水合自由基灭活。
Radiat Res. 1972 Dec;52(3):588-602.
7
The relevance of the superoxide anion radical in biological systems.超氧阴离子自由基在生物系统中的相关性。
Curr Top Radiat Res Q. 1974 May;9(3):247-309.
8
Chain reactions and radiosensitization: model enzyme studies.链式反应与放射增敏作用：模型酶研究
Int J Radiat Biol Relat Stud Phys Chem Med. 1975 Apr;27(4):389-98. doi: 10.1080/09553007514550361.
9
Photochemical inactivation of enzymes.酶的光化学失活
Curr Top Radiat Res Q. 1976 Mar;11(2):141-99.
10
Radiation chemistry of amino acids and peptides in aqueous solutions.水溶液中氨基酸和肽的辐射化学
J Agric Food Chem. 1978 Jan-Feb;26(1):6-14. doi: 10.1021/jf60215a054.