对乙酰氨基酚吸收对胃排空速率的依赖性。
The dependence of paracetamol absorption on the rate of gastric emptying.
作者信息
Heading R C, Nimmo J, Prescott L F, Tothill P
出版信息
Br J Pharmacol. 1973 Feb;47(2):415-21. doi: 10.1111/j.1476-5381.1973.tb08339.x.
Abstract
- The rate of gastric emptying was measured directly in 14 convalescent hospital patients and paracetamol absorption was studied following an oral dose of 1.5 g.2. Rapid gastric emptying was associated with the early appearance of high peak plasma paracetamol concentrations whereas peak concentrations were low and occurred late when gastric emptying was slow.3. There was a significant correlation between the rate of gastric emptying and the 0-4 and 0-24 h urinary excretion of paracetamol and its metabolites.4. In five patients with abnormally slow gastric emptying the mean maximum plasma concentration and 0-4 and 0-24 h urinary excretion of paracetamol were significantly lower than in seven patients with normal gastric emptying rates while the time taken to reach maximum plasma concentrations was longer.5. Individual differences in the rate of gastric emptying may contribute to variable absorption of many drugs.
摘要
对14名康复期医院患者直接测量胃排空速率，并在口服1.5克对乙酰氨基酚后研究其吸收情况。
胃排空迅速与血浆对乙酰氨基酚浓度高峰提前出现相关，而胃排空缓慢时高峰浓度较低且出现较晚。
胃排空速率与对乙酰氨基酚及其代谢产物0至4小时和0至24小时尿排泄量之间存在显著相关性。
5名胃排空异常缓慢的患者，对乙酰氨基酚的平均最大血浆浓度以及0至4小时和0至24小时尿排泄量显著低于7名胃排空速率正常的患者，而达到最大血浆浓度所需时间更长。
胃排空速率的个体差异可能导致许多药物吸收的变异性。
相似文献
1
The dependence of paracetamol absorption on the rate of gastric emptying.对乙酰氨基酚吸收对胃排空速率的依赖性。
Br J Pharmacol. 1973 Feb;47(2):415-21. doi: 10.1111/j.1476-5381.1973.tb08339.x.
2
Pharmacological modification of gastric emptying: effects of propantheline and metoclopromide on paracetamol absorption.胃排空的药理学调节：丙胺太林和甲氧氯普胺对扑热息痛吸收的影响。
Br Med J. 1973 Mar 10;1(5853):587-9. doi: 10.1136/bmj.1.5853.587.
3
The relationship between gastric emptying of semisolids and paracetamol absorption.半固体食物的胃排空与对乙酰氨基酚吸收之间的关系。
Br J Clin Pharmacol. 1986 Dec;22(6):659-62. doi: 10.1111/j.1365-2125.1986.tb02954.x.
4
Effect of intravenous atropine on gastric emptying, paracetamol absorption, salivary flow and heart rate in young and fit elderly volunteers.静脉注射阿托品对年轻健康老年志愿者胃排空、对乙酰氨基酚吸收、唾液分泌及心率的影响。
Br J Clin Pharmacol. 1990 Jul;30(1):25-34. doi: 10.1111/j.1365-2125.1990.tb03739.x.
5
Plasma paracetamol concentrations measured by fluorescence polarization immunoassay and gastric emptying time.
Tohoku J Exp Med. 1988 Jun;155(2):159-64. doi: 10.1620/tjem.155.159.
6
Narcotic analgesics and delayed gastric emptying during labour.
Lancet. 1975 Apr 19;1(7912):890-3. doi: 10.1016/s0140-6736(75)91687-6.
7
Validation of the paracetamol absorption test for measuring gastric tube emptying in esophagectomized patients versus gold standard scintigraphy.对乙酰氨基酚吸收试验用于测量食管切除患者胃管排空情况与金标准闪烁扫描法的对比验证
Scand J Gastroenterol. 2015;50(11):1339-47. doi: 10.3109/00365521.2015.1041151. Epub 2015 Jun 12.
8
Kinetics of acetaminophen absorption and gastric emptying in man.对乙酰氨基酚在人体中的吸收动力学及胃排空情况
Clin Pharmacol Ther. 1978 Oct;24(4):420-31. doi: 10.1002/cpt1978244420.
9
The measurement of gastric emptying during labour.
J Int Med Res. 1978;6 Suppl 1:52-3.
10
Gastric emptying and drug absorption before surgery.
Br J Anaesth. 1984 Feb;56(2):161-4. doi: 10.1093/bja/56.2.161.
引用本文的文献
1
Inhibition of basal IL-6 activity promotes subcutaneous fat retention in humans during fasting and postprandial states.抑制基础白细胞介素-6活性可促进人类在禁食和餐后状态下皮下脂肪的保留。
Cell Rep Med. 2025 Apr 15;6(4):102042. doi: 10.1016/j.xcrm.2025.102042. Epub 2025 Mar 26.
2
Pharmacokinetic profile of novel multi-layer stable effervescent tablet: a cross-over study with an established European brand in healthy young male adults.新型多层稳定泡腾片的药代动力学特征：一项在健康年轻男性成年人中与已上市的欧洲品牌进行的交叉研究。
BMC Pharmacol Toxicol. 2024 Nov 5;25(1):83. doi: 10.1186/s40360-024-00808-9.
3
Fasting before Intra-Gastric Dosing with Antigen Improves Intestinal Humoral Responses in Syrian Hamsters.抗原胃内给药前禁食可改善叙利亚仓鼠的肠道体液免疫反应。
Vaccines (Basel). 2024 May 24;12(6):572. doi: 10.3390/vaccines12060572.
4
Development of Efficient Sodium Alginate/Polysuccinimide-Based Hydrogels as Biodegradable Acetaminophen Delivery Systems.开发高效的海藻酸钠/聚琥珀酰亚胺基水凝胶作为可生物降解的对乙酰氨基酚递送系统。
Gels. 2023 Dec 14;9(12):980. doi: 10.3390/gels9120980.
5
Determination of Gastric Water Emptying in Fasted and Fed State Conditions Using a Compression-Coated Tablet and Salivary Caffeine Kinetics.使用压制包衣片和唾液咖啡因动力学测定禁食和进食状态下的胃排空情况。
Pharmaceutics. 2023 Nov 4;15(11):2584. doi: 10.3390/pharmaceutics15112584.
6
Cinnamon Oil Alleviates Acetaminophen-Induced Uterine Toxicity in Rats by Abrogation of Oxidative Stress, Apoptosis, and Inflammation.肉桂油通过消除氧化应激、细胞凋亡和炎症来减轻对乙酰氨基酚诱导的大鼠子宫毒性。
Plants (Basel). 2023 Jun 12;12(12):2290. doi: 10.3390/plants12122290.
7
Effect of Food and a Proton-Pump Inhibitor on the Absorption of Encorafenib: An -- Approach.食物和质子泵抑制剂对恩考芬尼吸收的影响：一种 -- 方法。
Mol Pharm. 2023 May 1;20(5):2589-2599. doi: 10.1021/acs.molpharmaceut.3c00016. Epub 2023 Apr 10.
8
Comparing Salivary Caffeine Kinetics of C and C Caffeine for Gastric Emptying of 50 mL Water.比较C型和CC型咖啡因的唾液咖啡因动力学对50毫升水胃排空的影响。
Pharmaceutics. 2023 Jan 18;15(2):328. doi: 10.3390/pharmaceutics15020328.
9
Delayed Gastric Emptying and Gastric Remnant Function After Pancreaticoduodenectomy: A Systematic Review of Objective Assessment Modalities.胰十二指肠切除术后胃排空和胃残留功能延迟：客观评估方式的系统评价。
World J Surg. 2023 Jan;47(1):236-259. doi: 10.1007/s00268-022-06784-7. Epub 2022 Oct 23.
10
FOXO1 Is Present in Stomach Epithelium and Determines Gastric Cell Distribution.FOXO1存在于胃上皮中并决定胃细胞分布。
Gastro Hep Adv. 2022;1(5):733-745. doi: 10.1016/j.gastha.2022.05.005. Epub 2022 May 14.
本文引用的文献
1
An evaluation of indium DTPA chelate in the measurement of gastric emptying by scintiscanning.铟 DTPA 螯合物在闪烁扫描法测定胃排空中的评价。
Gut. 1971 Aug;12(8):611-5. doi: 10.1136/gut.12.8.611.
2
The absorption characteristics of paracetamol tablets in man.对乙酰氨基酚片在人体中的吸收特性。
J Pharm Pharmacol. 1963 Jul;15:445-53. doi: 10.1111/j.2042-7158.1963.tb12812.x.
3
The effect of ethanol on the gastrointestinal absorption of drugs in the rat.
Acta Pharmacol Toxicol (Copenh). 1968;26(2):130-44. doi: 10.1111/j.1600-0773.1968.tb00433.x.
4
Physiological factors affecting intestinal drug absorption.影响肠道药物吸收的生理因素。
Eur J Pharmacol. 1970 Jul 1;11(1):109-14. doi: 10.1016/0014-2999(70)90261-x.
5
Absorption of acetylsalicylic acid b a normal and an atrophic gastic mucosa.乙酰水杨酸在正常和萎缩性胃黏膜中的吸收情况。
Scand J Gastroenterol. 1969;4(3):269-73.
6
Generic inequivalence--clinical observations.
Acta Pharmacol Toxicol (Copenh). 1971;29 Suppl 3:288-303. doi: 10.1111/j.1600-0773.1971.tb03308.x.
7
Pharmacokinetic of procainamide in man.普鲁卡因酰胺在人体中的药代动力学。
Ann N Y Acad Sci. 1971 Jul 6;179:370-82. doi: 10.1111/j.1749-6632.1971.tb46914.x.
8
Metabolism and absorption of L-3,4 dihydroxyphenylalanine in patients with Parkinson's disease.帕金森病患者中L-3,4-二羟基苯丙氨酸的代谢与吸收
Ann N Y Acad Sci. 1971 Jul 6;179:126-40. doi: 10.1111/j.1749-6632.1971.tb46895.x.
9
Multicompartment analysis of the absorption kinetics of warfarin from the stomach and small intestine.华法林从胃和小肠吸收动力学的多室分析。
Int Z Klin Pharmakol Ther Toxikol. 1971 Oct;5(2):209-11.
10
Drug absorption. V. Influence of food on oral absorption of phenobarbital in rats.
J Pharm Sci. 1971 Nov;60(11):1639-41. doi: 10.1002/jps.2600601109.
Zotero 插件