半固体食物的胃排空与对乙酰氨基酚吸收之间的关系。
The relationship between gastric emptying of semisolids and paracetamol absorption.
作者信息
Petring O U, Adelhøj B, Ibsen M, Poulsen H E
出版信息
Br J Clin Pharmacol. 1986 Dec;22(6):659-62. doi: 10.1111/j.1365-2125.1986.tb02954.x.
Abstract
The relationship between gastric emptying rate of semisolid Tc-99m labelled Chelex-100 resin/oatmeal and paracetamol absorption was determined simultaneously in seven healthy volunteers. There was no significant correlation between the half-time of gastric emptying and the time of the peak serum paracetamol concentration. There was no significant correlation between the area under the serum paracetamol concentrations at 60 and 90 min and the % meal emptied in 60 and 90 min respectively. Three subjects showed a lag phase in gastric emptying pattern, while the other four showed the emptying curves without evidence of a delayed phase of emptying. Individual values of gastric emptying determined by the methods varied widely.
摘要
在7名健康志愿者中同时测定了半固体99m锝标记的螯合树脂/燕麦片的胃排空率与对乙酰氨基酚吸收之间的关系。胃排空半衰期与血清对乙酰氨基酚浓度峰值时间之间无显著相关性。血清对乙酰氨基酚浓度在60分钟和90分钟时的曲线下面积分别与60分钟和90分钟内排空的食物百分比之间无显著相关性。3名受试者的胃排空模式显示有一个延迟期，而其他4名受试者的排空曲线没有显示出排空延迟期的迹象。通过这些方法测定的胃排空个体值差异很大。
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