• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

用不同浓度的(-)-3H-去甲肾上腺素对神经元内去甲肾上腺素储存进行差异标记。

Differential labelling of intraneuronal noradrenaline stores with different concentrations of (-)-3H-noradrenaline.

作者信息

Hughes J

出版信息

Br J Pharmacol. 1973 Feb;47(2):428-30. doi: 10.1111/j.1476-5381.1973.tb08342.x.

DOI:10.1111/j.1476-5381.1973.tb08342.x
PMID:4722053
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1776551/
Abstract

Isolated preparations of the rabbit vas deferens were incubated with (--)-(3)H-nor- adrenaline. A preferential release of (3)H-noradrenaline was demonstrated after electrical stimulation of the intramural nerves in those tissues labelled with 10 ng/ml (3)H-noradrenaline. There was no preferential release of (3)H-noradrenaline when the vasa were initially labelled with 100 ng/ml (3)H-noradrenaline. It is concluded that low concentrations of (3)H-noradrenaline do not mix homogeneously with the total tissue store but enter a small easily releasable store.

摘要

将兔输精管的离体标本与(--)-(3)H-去甲肾上腺素一起孵育。在用10 ng/ml(3)H-去甲肾上腺素标记的那些组织中,电刺激壁内神经后,显示出(3)H-去甲肾上腺素的优先释放。当输精管最初用100 ng/ml(3)H-去甲肾上腺素标记时,没有(3)H-去甲肾上腺素的优先释放。得出的结论是,低浓度的(3)H-去甲肾上腺素不会与整个组织储存均匀混合,而是进入一个小的易于释放的储存库。

相似文献

1
Differential labelling of intraneuronal noradrenaline stores with different concentrations of (-)-3H-noradrenaline.用不同浓度的(-)-3H-去甲肾上腺素对神经元内去甲肾上腺素储存进行差异标记。
Br J Pharmacol. 1973 Feb;47(2):428-30. doi: 10.1111/j.1476-5381.1973.tb08342.x.
2
Effect of blockade of noradrenaline re-uptake on evoked tritium overflow from mouse vasa deferentia and rat cortex slices.去甲肾上腺素再摄取阻断对小鼠输精管和大鼠皮层切片诱发的氚溢出的影响。
Br J Pharmacol. 1990 Nov;101(3):762-8. doi: 10.1111/j.1476-5381.1990.tb14153.x.
3
Evaluation of mechanisms controlling the release and inactivation of the adrenergic transmitter in the rabbit portal vein and vas deferens.家兔门静脉和输精管中肾上腺素能递质释放及失活调控机制的评估
Br J Pharmacol. 1972 Mar;44(3):472-91. doi: 10.1111/j.1476-5381.1972.tb07285.x.
4
Differential distribution in, and release from, sympathetic nerve endings of endogenous noradrenaline and recently incorporated catecholamines.内源性去甲肾上腺素和近期摄取的儿茶酚胺在交感神经末梢中的差异分布及其释放情况。
Naunyn Schmiedebergs Arch Pharmacol. 1990 Aug;342(2):153-9. doi: 10.1007/BF00166958.
5
Chronic inhibition of monoamine oxidase reduces noradrenaline release in rat vas deferens and anococcygeus muscle.单胺氧化酶的慢性抑制降低大鼠输精管和肛尾肌中的去甲肾上腺素释放。
Naunyn Schmiedebergs Arch Pharmacol. 1987 Jul;336(1):70-6. doi: 10.1007/BF00177753.
6
Variation in noradrenaline output with changes in stimulus frequency and train length: role of different noradrenaline pools.去甲肾上腺素释放量随刺激频率和串长变化的差异:不同去甲肾上腺素池的作用
Br J Pharmacol. 1974 Jul;51(3):373-81. doi: 10.1111/j.1476-5381.1974.tb10672.x.
7
Inhibition of noradrenaline release by lysergic acid diethylamide.麦角酸二乙胺对去甲肾上腺素释放的抑制作用。
Br J Pharmacol. 1973 Dec;49(4):706-8. doi: 10.1111/j.1476-5381.1973.tb08549.x.
8
Evidence that angiotensin enhances transmitter release during sympathetic nerve stimulation.有证据表明,在交感神经刺激期间,血管紧张素可增强递质释放。
Br J Pharmacol. 1971 Feb;41(2):239-55. doi: 10.1111/j.1476-5381.1971.tb08025.x.
9
The effect of delta1-tetrahydrocannabinol on the release of (3H-(-)-noradrenaline from the isolated vas deferens of the rat.δ1-四氢大麻酚对大鼠离体输精管释放(3H-(-)-去甲肾上腺素的影响。
Br J Pharmacol. 1974 Oct;52(2):233-6. doi: 10.1111/j.1476-5381.1974.tb09705.x.
10
Effect of the dihydropyridine Bay K 8644 on the release of [3H]-noradrenaline from the rat isolated vas deferens.二氢吡啶类药物Bay K 8644对大鼠离体输精管释放[3H]-去甲肾上腺素的影响。
Br J Pharmacol. 1985 Jul;85(3):691-6. doi: 10.1111/j.1476-5381.1985.tb10565.x.

引用本文的文献

1
Effects of tyramine and calcium on the kinetics of secretion in intact and electroporated chromaffin cells superfused at high speed.酪胺和钙对高速灌流的完整嗜铬细胞和电穿孔嗜铬细胞分泌动力学的影响。
Pflugers Arch. 1995 Dec;431(2):283-96. doi: 10.1007/BF00410202.
2
Homogeneous or heterogeneous distribution of systemically administered adrenaline: organ dependence.全身给药肾上腺素的均匀或非均匀分布:器官依赖性。
Naunyn Schmiedebergs Arch Pharmacol. 1996 Apr;353(5):579-83. doi: 10.1007/BF00169179.
3
A comparative study of the distribution of tritiated and endogenous noradrenaline in the rat vas deferens and in the dog spleen capsule.氚标记的去甲肾上腺素与内源性去甲肾上腺素在大鼠输精管和犬脾包膜中分布的比较研究。
Naunyn Schmiedebergs Arch Pharmacol. 1993 Nov;348(5):466-71. doi: 10.1007/BF00173204.
4
Stimulation-evoked release of [3H]-noradrenaline by 1, 10 or 100 pulses and its modification through presynaptic alpha 2-adrenoceptors.1、10或100个脉冲刺激诱发的[3H] -去甲肾上腺素释放及其通过突触前α2 -肾上腺素能受体的调节。
Br J Pharmacol. 1983 Jan;78(1):221-31. doi: 10.1111/j.1476-5381.1983.tb09383.x.
5
Site(s) and ionic basis of alpha-autoinhibition and facilitation of "3H'noradrenaline secretion in guinea-pig vas deferens.豚鼠输精管中α-自身抑制及“3H”去甲肾上腺素分泌促进作用的位点及离子基础。
J Physiol. 1981 Mar;312:297-334. doi: 10.1113/jphysiol.1981.sp013630.
6
The effects of indomethacin and eicosa-5,8,11,14-tetraynoic acid on the response of the rabbit portal vein to electrical stimulation.吲哚美辛和5,8,11,14-二十碳四炔酸对兔门静脉电刺激反应的影响。
Br J Pharmacol. 1974 Sep;52(1):61-8. doi: 10.1111/j.1476-5381.1974.tb09687.x.
7
Variation in noradrenaline output with changes in stimulus frequency and train length: role of different noradrenaline pools.去甲肾上腺素释放量随刺激频率和串长变化的差异:不同去甲肾上腺素池的作用
Br J Pharmacol. 1974 Jul;51(3):373-81. doi: 10.1111/j.1476-5381.1974.tb10672.x.
8
Frequency dependence of dual negative feedback control of secretion of sympathetic neurotransmitter in guinea-pig vas deferens.豚鼠输精管中交感神经递质分泌的双负反馈控制的频率依赖性
Br J Pharmacol. 1973 Oct;49(2):358-60. doi: 10.1111/j.1476-5381.1973.tb08383.x.
9
Simulation of outward transport of neuronal 3H-noradrenaline with the help of a two-compartment model.借助双室模型模拟神经元3H-去甲肾上腺素的外向转运。
Naunyn Schmiedebergs Arch Pharmacol. 1987 Dec;336(6):631-40. doi: 10.1007/BF00165753.
10
A kinetic study of the release of noradrenaline by electrical stimulation: influence of presynaptic alpha-adrenoceptors.电刺激释放去甲肾上腺素的动力学研究:突触前α-肾上腺素能受体的影响
Naunyn Schmiedebergs Arch Pharmacol. 1985 Jan;328(3):248-52. doi: 10.1007/BF00515549.

本文引用的文献

1
The uptake and disposition of dl-norepinephrine in perfused rat lung.去甲肾上腺素在灌注大鼠肺中的摄取与分布
J Pharmacol Exp Ther. 1969 Oct;169(2):237-48.
2
Selective release of newly synthesized norepinephrine from the cat spleen during sympathetic nerve stimulation.交感神经刺激期间猫脾脏中新合成去甲肾上腺素的选择性释放。
J Pharmacol Exp Ther. 1968 Jun;161(2):271-8.
3
A fluorometric assay for subnanogram concentrations of adrenaline and noradrenaline in plasma.一种用于测定血浆中亚纳克级浓度肾上腺素和去甲肾上腺素的荧光测定法。
Anal Biochem. 1970 Apr;34(2):568-81. doi: 10.1016/0003-2697(70)90142-9.
4
Variations in noradrenaline output with respect to stimulus frequency, train length and origin of the transmitter.去甲肾上腺素输出量随刺激频率、串长及递质来源的变化。
Br J Pharmacol. 1972 May;45(1):157P.
5
Transport and storage of biogenic amines.生物胺的运输与储存。
Annu Rev Pharmacol. 1972;12:209-26. doi: 10.1146/annurev.pa.12.040172.001233.
6
Evaluation of mechanisms controlling the release and inactivation of the adrenergic transmitter in the rabbit portal vein and vas deferens.家兔门静脉和输精管中肾上腺素能递质释放及失活调控机制的评估
Br J Pharmacol. 1972 Mar;44(3):472-91. doi: 10.1111/j.1476-5381.1972.tb07285.x.
7
The relative role of recapture and of de novo synthesis for the maintenance of neurotransmitter homeostasis in noradrenergic nerves.再摄取和从头合成在去甲肾上腺素能神经中维持神经递质稳态的相对作用。
Acta Physiol Scand. 1969 Jul;76(3):270-83. doi: 10.1111/j.1748-1716.1969.tb04470.x.