用不同浓度的（-）-3H-去甲肾上腺素对神经元内去甲肾上腺素储存进行差异标记。
Differential labelling of intraneuronal noradrenaline stores with different concentrations of (-)-3H-noradrenaline.
作者信息
Hughes J
出版信息
Br J Pharmacol. 1973 Feb;47(2):428-30. doi: 10.1111/j.1476-5381.1973.tb08342.x.
Abstract
Isolated preparations of the rabbit vas deferens were incubated with (--)-(3)H-nor- adrenaline. A preferential release of (3)H-noradrenaline was demonstrated after electrical stimulation of the intramural nerves in those tissues labelled with 10 ng/ml (3)H-noradrenaline. There was no preferential release of (3)H-noradrenaline when the vasa were initially labelled with 100 ng/ml (3)H-noradrenaline. It is concluded that low concentrations of (3)H-noradrenaline do not mix homogeneously with the total tissue store but enter a small easily releasable store.
摘要
将兔输精管的离体标本与（--）-（3）H-去甲肾上腺素一起孵育。在用10 ng/ml（3）H-去甲肾上腺素标记的那些组织中，电刺激壁内神经后，显示出（3）H-去甲肾上腺素的优先释放。当输精管最初用100 ng/ml（3）H-去甲肾上腺素标记时，没有（3）H-去甲肾上腺素的优先释放。得出的结论是，低浓度的（3）H-去甲肾上腺素不会与整个组织储存均匀混合，而是进入一个小的易于释放的储存库。
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