δ1-四氢大麻酚对大鼠离体输精管释放（3H-（-）-去甲肾上腺素的影响。
The effect of delta1-tetrahydrocannabinol on the release of (3H-(-)-noradrenaline from the isolated vas deferens of the rat.
作者信息
Graham J D, Lewis M J, Li D M
出版信息
Br J Pharmacol. 1974 Oct;52(2):233-6. doi: 10.1111/j.1476-5381.1974.tb09705.x.
1 The amount of tritium released upon transmural stimulation of the isolated vas of the rat incubated with [(3)H]-Delta(1)-tetrahydrocannabinol (THC) (2.8 muM) was significantly greater than the non-stimulated overflow.2 There was no difference between non-stimulated overflow and the effect of transmural stimulation of vasa equilibrated with [(14)C]-sorbitol (6.5 mg/ml).3 The difference between non-stimulated and stimulated efflux from vasa equilibrated with [(3)H]-Delta(1)-THC was abolished in rats pretreated for 24 h with 6-hydroxydopamine (250 mg/kg).4 The amount of tritium released upon transmural stimulation of the vas incubated with [(3)H]-noradrenaline (6 muM) was significantly greater than the non-stimulated overflow.5 Delta(1)-THC (560 nM and 14 muM) caused a significant dose-dependent reduction of both non-stimulated and stimulated tritium efflux, especially the latter.
用[(3)H]-Δ(1)-四氢大麻酚（THC）（2.8 μM）孵育大鼠离体血管，经透壁刺激后释放的氚量显著高于未刺激时的溢出量。
未刺激时的溢出量与用[(14)C]-山梨醇（6.5 mg/ml）平衡血管后的透壁刺激效果之间无差异。
用6-羟基多巴胺（250 mg/kg）预处理24小时的大鼠，用[(3)H]-Δ(1)-THC平衡血管后，未刺激和刺激时流出量的差异消失。
用[(3)H]-去甲肾上腺素（6 μM）孵育血管，经透壁刺激后释放的氚量显著高于未刺激时的溢出量。
Δ(1)-THC（560 nM和14 μM）引起未刺激和刺激时氚流出量显著的剂量依赖性降低，尤其是后者。
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