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脑匀浆中内源性前列腺素生物合成的区域和物种差异。

Regional and species differences in endogenous prostaglandin biosynthesis by brain homogenates.

作者信息

Abdel-Halim M S, Anggård E

出版信息

Prostaglandins. 1979 Mar;17(3):411-8. doi: 10.1016/s0090-6980(79)80009-x.

DOI:10.1016/s0090-6980(79)80009-x
PMID:472337
Abstract

Endogenously formed prostaglandins (PGs) D2, E2 and F2 alpha were determined in homogenates of brain regions from rat, guinea-pig, rabbit and cat, using gas-chromatography-mass spectrometry. The main PGs formed in the brain regions of the rat were PGD2, in the guinea-pig PGD2 and PGF2 alpha, in the rabbit PGF2 alpha and in the cat PGE2. Brain regions from the same animal species showed the same pattern of PG formation. They varied, however, in the amount of total PGs formed, the limbic system and the cerebral cortex being highest and cerebellum lowest.

摘要

利用气相色谱 - 质谱联用技术，测定了大鼠、豚鼠、兔和猫脑区匀浆中内源性生成的前列腺素（PGs）D2、E2和F2α。大鼠脑区生成的主要PGs是PGD2，豚鼠是PGD2和PGF2α，兔是PGF2α，猫是PGE2。同一动物物种的脑区显示出相同的PG生成模式。然而，它们在生成的总PGs量上有所不同，边缘系统和大脑皮层最高，小脑最低。

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Role of prostaglandin D2 in the hypothermia of rats caused by bacterial lipopolysaccharide.
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Psychopharmacology (Berl). 1982;78(4):317-21. doi: 10.1007/BF00433733.
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Effects of intracerebroventricular administration of prostaglandin D2 on behaviour, blood pressure and body temperature as compared to prostaglandins E2 and F2 alpha.与前列腺素E2和F2α相比，脑室内注射前列腺素D2对行为、血压和体温的影响。
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