花生四烯酸、前列腺素E2、前列腺素F2α、前列腺素D2和前列环素对大鼠胃分泌的中枢神经系统效应
Central nervous system effects of arachidonic acid, PGE2, PGF2 alpha, PGD2 and PGI2 on gastric secretion in the rat.
作者信息
Puurunen J
出版信息
Br J Pharmacol. 1983 Oct;80(2):255-62. doi: 10.1111/j.1476-5381.1983.tb10028.x.
The effects of arachidonic acid, prostaglandin E2 (PGE2), PGF2 alpha, PGD2 and PGI2 on gastric secretion (acid, pepsin and volume) after intracerebroventricular administration were investigated in conscious, pylorus-ligated rats. Arachidonic acid 30-1000 micrograms had no effect on gastric secretion. PGE2 3 and 10 micrograms, reduced gastric secretion as measured 1 hour after injection, although the inhibition induced by 3 micrograms disappeared by 2 h. PGF2 alpha 10 and 30 micrograms, inhibited gastric secretion as measured after 1 h, whereas no change was observed in the gastric contents collected 2 h after 10 micrograms of PGF2 alpha. Intramuscular injection of 30 micrograms of PGF2 alpha had no effect on gastric secretion. Intracerebroventricular administration of 1-30 micrograms of PGD2 or PGI2 had no effect on gastric secretion. The results indicate that PGE2 and PGF2 alpha have a potent central antisecretory action in conscious, pylorus-ligated rats, whereas arachidonic acid, PGD2 and PGI2 do not have any central effects on gastric secretion. It is suggested that PGE2 and PGF2 alpha may be involved in the central nervous system control of gastric secretion.
在清醒的幽门结扎大鼠中，研究了脑室内注射花生四烯酸、前列腺素E2（PGE2）、前列腺素F2α（PGF2α）、前列腺素D2（PGD2）和前列环素（PGI2）对胃分泌（胃酸、胃蛋白酶和胃液量）的影响。30 - 1000微克的花生四烯酸对胃分泌无影响。3微克和10微克的PGE2在注射后1小时可减少胃分泌，不过3微克诱导的抑制作用在2小时后消失。10微克和30微克的PGF2α在1小时后可抑制胃分泌，而在注射10微克PGF2α后2小时收集的胃内容物中未观察到变化。肌肉注射30微克PGF2α对胃分泌无影响。脑室内注射1 - 30微克的PGD2或PGI2对胃分泌无影响。结果表明，PGE2和PGF2α在清醒的幽门结扎大鼠中具有强大的中枢性抗分泌作用，而花生四烯酸、PGD2和PGI2对胃分泌没有任何中枢作用。提示PGE2和PGF2α可能参与了胃分泌的中枢神经系统控制。
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