Mallette L E, Patten B M, Engel W K
Ann Intern Med. 1975 Apr;82(4):474-83. doi: 10.7326/0003-4819-82-4-474.
Neuromuscular function was evaluated in six patients with osteomalacia or secondary hyperparathyroidism, or both, as demonstrated by bone biopsy showing osteomalacia or increased immunoreactive parathyroid hormone, or both. Each patient had weakness, atrophy, and fatigability of proximal muscles, especially of the lower extremities. Most also showed involuntary fine movements of the tongue, hyperactive tendon reflexes with abnormal spread, and decreased vibration sensation, abnormalities similar to those observed in primary hyperparathyroidism. Every patient studies had evidence of neuropathic muscle disease, either on electromyography or muscle biopsy studies histochemically or both. Muscle biopsies showed no definite myopathic features. Treatment of the osteomalacia improved muscle strength. Patients with osteomalacia therefore have a treatable neuromuscular disease that is neuropathic in nature and resembles closely that found in primary hyperparathyroidism.
对6例骨软化症或继发性甲状旁腺功能亢进症或两者皆有的患者进行了神经肌肉功能评估，骨活检显示有骨软化症或免疫反应性甲状旁腺激素升高或两者皆有。每位患者均有近端肌肉无力、萎缩和易疲劳，尤其是下肢。大多数患者还表现出舌头不自主的细微运动、腱反射亢进伴异常扩散以及振动觉减退，这些异常与原发性甲状旁腺功能亢进症中观察到的相似。每个接受研究的患者在肌电图检查、肌肉活检组织化学检查或两者中均有神经性肌肉疾病的证据。肌肉活检未显示明确的肌病特征。骨软化症的治疗改善了肌肉力量。因此，骨软化症患者有一种可治疗的神经肌肉疾病，其本质是神经性的，与原发性甲状旁腺功能亢进症中发现的疾病非常相似。
