Beattie A D, Moore M R, Goldberg A, Ward R L
Br Med J. 1973 Aug 4;3(5874):257-60. doi: 10.1136/bmj.3.5874.257.
In four young adult patients with acute attacks of acute intermittent porphyria tachycardia and hypertension were prominent features of the illness. Urinary catecholamine excretion was increased in both patients in whom it was measured. The effect of the beta-adrenergic blocking drug propranolol was assessed in each case. The dose varied from 40 to 240 mg daily. A response in the form of a reduction in heart rate and blood pressure was noted in each case, and in one case a marked alleviation of abdominal pain followed administration of the drug.Propranolol, when given in high dosage to rats, did not induce an increase in hepatic delta-aminolaevulic acid synthetase, an enzyme which is raised in human and drug-induced animal porphyria. The use of propranolol is therefore unlikely to aggravate or precipitate an attack of acute intermittent porphyria.
在4例急性间歇性卟啉病急性发作的年轻成年患者中，心动过速和高血压是该病的突出特征。在测定尿儿茶酚胺排泄量的2例患者中，其排泄量均增加。对每例患者均评估了β-肾上腺素能阻滞剂普萘洛尔的效果。剂量为每日40至240毫克。每例患者均出现心率和血压降低的反应，在1例患者中，用药后腹痛明显缓解。给大鼠高剂量普萘洛尔时，不会诱导肝δ-氨基-γ-酮戊酸合成酶增加，该酶在人类和药物诱导的动物卟啉病中会升高。因此，使用普萘洛尔不太可能加重或诱发急性间歇性卟啉病发作。
