心房和心室起搏器活动的同步测量。
Simultaneous measurement of atrial and ventricular pacemaker activity.
作者信息
Cavoto F, Kelliher G, Roberts J
出版信息
Br J Pharmacol. 1973 Apr;47(4):843-6. doi: 10.1111/j.1476-5381.1973.tb08212.x.
The isolated perfused rat heart with surgically-induced heart block was used to determine the effect of drugs on the activity of the atrial and ventricular pacemaker simultaneously. Complete atrio-ventricular dissociation was produced by tying a ligature around the Bundle of His under direct vision. Pacemaker rates remained stable for at least 2 hours. Perfusion of the hearts with quinidine produced a decrease in the rate of both the atrial and ventricular pacemaker. The ventricular pacemaker was more susceptible to the depressant action of quinidine than the atrial pacemaker.
采用手术诱导心脏传导阻滞的离体灌注大鼠心脏，同时测定药物对心房和心室起搏器活性的影响。在直视下围绕希氏束结扎线，造成完全性房室分离。起搏器频率至少保持稳定2小时。用奎尼丁灌注心脏，可使心房和心室起搏器的频率均降低。心室起搏器比心房起搏器对奎尼丁的抑制作用更敏感。
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