甘珀酸钠对大鼠应激性胃损伤的影响。
Effects of carbenoxolone sodium on stress-induced gastric damage in rats.
作者信息
Perkins W E, Vars L
出版信息
Br J Pharmacol. 1973 Apr;47(4):847-9. doi: 10.1111/j.1476-5381.1973.tb08213.x.
Carbenoxolone sodium was studied to determine its effect against restraint-induced gastric mucosal damage in the rat. Significant anti-ulcer activity was observed following intraperitoneal administration in nonfasted but not in either 24 or 48 h fasted rats. Orally, carbenoxolone had no statistically significant effect in non-fasted rats although the data suggest that it may have afforded some protection. These results indicate that the use of non-fasted rats is most probably a requirement for demonstrating the protective activity of this type of anti-ulcer compound in stressed rat assays.
研究了甘珀酸钠对大鼠束缚诱导的胃黏膜损伤的作用。在非禁食大鼠腹腔注射后观察到显著的抗溃疡活性，但在禁食24小时或48小时的大鼠中未观察到。口服时，甘珀酸钠在非禁食大鼠中没有统计学上的显著作用，尽管数据表明它可能提供了一些保护。这些结果表明，在应激大鼠试验中，使用非禁食大鼠很可能是证明这类抗溃疡化合物保护活性的必要条件。
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