甘珀酸和甘草次酸对胃蛋白酶活性的抑制作用。
Inhibition of peptic activity by carbenoxolone and glycyrrhetinic acid.
作者信息
Henman F D
出版信息
Gut. 1970 Apr;11(4):344-51. doi: 10.1136/gut.11.4.344.
Abstract
Carbenoxolone (Biogastrone, Berk) has been shown to reduce the peptic activity and total acidity of gastric juice obtained from anaesthetized pylorus-ligated rats without affecting significantly the volume of gastric juice secreted or the K(+) concentration. Glycyrrhetinic acid was less potent in reducing peptic activity and caused no reduction in total acidity. Antipeptic activity of carbenoxolone has also been demonstrated in vitro using the pepsin plate technique and the haemoglobin pepsin assay.It is suggested that these actions of carbenoxolone may contribute to the increased rate of healing of peptic ulcer in patients treated with the drug.
摘要
生胃酮（甘珀酸，伯克公司生产）已被证明可降低从麻醉的幽门结扎大鼠获得的胃液的消化活性和总酸度，而对分泌的胃液量或钾离子浓度无显著影响。甘草次酸在降低消化活性方面作用较弱，且不会降低总酸度。使用胃蛋白酶平板技术和血红蛋白胃蛋白酶测定法，还在体外证明了生胃酮的抗消化活性。有人认为，生胃酮的这些作用可能有助于接受该药物治疗的消化性溃疡患者提高愈合率。
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