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向肝门静脉系统输注2-脱氧-D-葡萄糖会引发进食:外周葡萄糖感受器的证据。

Infusion of 2-deoxy-D-glucose into the hepatic-portal system causes eating: evidence for peripheral glucoreceptors.

作者信息

Novin D, VanderWeele D A, Rezek M

出版信息

Science. 1973 Aug 31;181(4102):858-60. doi: 10.1126/science.181.4102.858.

DOI:10.1126/science.181.4102.858
PMID:4724074
Abstract

Injections of 2-deoxyglucose into the hepatic-portal system of normal rabbits increased eating to a greater extent and with shorter latency than comparable injections of 2-deoxyglucose into the jugular vein or into the hepaticportal circulation of the vagotomized rabbit. These differences suggest the existence of vagally mediated peripheral glucoreceptors important in the initiation of food intake.

摘要

向正常兔子的肝门静脉系统注射2-脱氧葡萄糖,比向颈静脉或迷走神经切断的兔子的肝门静脉循环注射同等剂量的2-脱氧葡萄糖,能在更大程度上增加进食量,且潜伏期更短。这些差异表明,存在由迷走神经介导的外周葡萄糖感受器,它们在启动食物摄入方面很重要。

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