青春期前大鼠经酶促或饮食性去除天冬酰胺后组织中天冬酰胺的浓度。
Concentrations of asparagine in tissues of prepubertal rats after enzymic or dietary depletion of asparagine.
作者信息
Frankel D L, Wells H, Fillios L C
出版信息
Biochem J. 1973 Mar;132(3):645-8. doi: 10.1042/bj1320645.
Abstract
Growth of weanling rats was significantly depressed after 8 days of asparagine depletion produced by dietary means or by asparaginase treatment. Moreover, the concentration of free asparagine was significantly lowered in forebrain, skeletal muscle, liver, kidney, spleen and small intestines 3 h after an asparaginase injection, but remained lowered only in forebrain and skeletal muscle after 8 days of enzymic or dietary depletion of asparagine.
摘要
通过饮食方式或天冬酰胺酶处理使天冬酰胺缺乏8天后，断奶大鼠的生长显著受到抑制。此外，注射天冬酰胺酶3小时后，前脑、骨骼肌、肝脏、肾脏、脾脏和小肠中的游离天冬酰胺浓度显著降低，但在通过酶法或饮食法使天冬酰胺缺乏8天后，仅前脑和骨骼肌中的游离天冬酰胺浓度仍保持降低状态。
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本文引用的文献
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THE ROLE OF DISPENSABLE AMINO ACIDS IN THE NUTRITION OF THE RAT.非必需氨基酸在大鼠营养中的作用
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Hepatic RNA metabolism in male and female obese rats fed cholesterol.喂食胆固醇的雄性和雌性肥胖大鼠的肝脏RNA代谢
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Evaluation of L-asparagine metabolism in animals and man.动物和人类中L-天冬酰胺代谢的评估。
Cancer Res. 1970 Apr;30(4):929-35.
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Relationship between nucleic acids, histone and non-histone protein synthesis in human lymphocytes stimulated with phytohemagglutinin.植物血凝素刺激的人淋巴细胞中核酸、组蛋白和非组蛋白合成之间的关系。
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The dependence of DNA and RNA synthesis on protein synthesis in asparaginase-treated lymphoma cells.
Cancer Res. 1970 Feb;30(2):515-27.
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The importance of dispensable amino acids for maximal growth in the rat.大鼠最大生长所需非必需氨基酸的重要性。
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