Ross J G, Halliday W G
Res Vet Sci. 1979 Jan;26(1):41-6.
Three investigations are described in which non-dialysed and dialysed leucocyte lysates, 'transfer factor' prepared from the blood of sheep infected with Trichostrongylus axei successfully transferred immunity to challenge infection with that parasite in susceptible lambs. Similar leucocyte lysates from parasite-free lambs failed to transfer a similar resistance to challenge infection. 'Transfer factor' treatment produced a 30--72 per cent reduction in a total worm burden compared to susceptible control lambs. In the first two investigations the donor and recipient lambs were genetically dissimilar and in the third investigation were of different breeds. The resistance transfer was considered to operate independently of immune incompetence.
本文描述了三项研究，其中未透析和透析的白细胞裂解物，即从感染奥氏毛圆线虫的绵羊血液中制备的“转移因子”，成功地将对该寄生虫攻击感染的免疫力转移给了易感羔羊。来自无寄生虫羔羊的类似白细胞裂解物未能转移对攻击感染的类似抵抗力。与易感对照羔羊相比，“转移因子”治疗使总虫负荷降低了30%至72%。在前两项研究中，供体和受体羔羊在遗传上不相似，在第三项研究中，它们属于不同品种。抗性转移被认为独立于免疫缺陷而发挥作用。
