Soong T T, Nicolaides P, Yu C P, Soong S C
Respir Physiol. 1979 Jul;37(2):161-72. doi: 10.1016/0034-5687(79)90068-9.
Most physiological studies which made use of lung geometry have utilized average deterministic models of the tracheobronchial tree geometry, such as Weibel's Model A (1963). However, as shown by morphometric studies, it is well known that there are significant inter-subject and intra-subject variabilities in the structural components of the human lung. Hence, inherent inaccuracies exist when deterministic dimensions for lung geometry are used. In this paper, a statistical description of the lung geometry is presented. Using Weibel's Model A as the underlying average model, probability distributions for the lengths and the diameters of airways and for the number and volume of alveoli are proposed based on morphometric data. As a check for consistency, the probability distribution of the functional residual capacity is derived from those associated with airways and alveoli and it is compared with reported data. Results of this comparison are favorable, suggesting that the statistical description presented herein represents a self-consistent model for lung geometry which can be used for studies of problems related to pulmonary physiology.
大多数利用肺部几何结构的生理学研究都采用了气管支气管树几何结构的平均确定性模型，如韦贝尔的A模型（1963年）。然而，形态计量学研究表明，众所周知，人类肺部的结构组成在个体间和个体内都存在显著差异。因此，使用肺部几何结构的确定性尺寸时存在固有的不准确性。本文提出了一种肺部几何结构的统计描述。以韦贝尔的A模型作为基础平均模型，基于形态计量学数据提出了气道长度和直径、肺泡数量和体积的概率分布。作为一致性检验，从与气道和肺泡相关的概率分布中推导出功能残气量的概率分布，并与报告数据进行比较。比较结果良好，表明本文提出的统计描述代表了一种肺部几何结构的自洽模型，可用于研究与肺生理学相关的问题。
