Comparative clinical study of the effects of Na isobutyrate and clofibrate on the clotting factors in patients with atherosclerosis.

The effects of Na isobutyrate and clofibrate on human hemostasis were studied in 24 patients with atherosclerosis. Significant changes were recorded only with respect to platelet adhesiveness and blood fibrinogen concentrations. Thus, the index of platelet adhesiveness decreased significantly in 17 out of 19 patients with high initial values, after six weeks of Na isobutyrate therapy (1 g/day), and in 9 out of 17 patients, after clofibrate administration (1.5 g/day) in the same conditions. Blood fibrinogen concentrations were significantly lowered by clofibrate therapy and only slightly influenced by Na isobutyrate.