Haddy T B, Lusher J M, Hendricks S, Trosko B K
Scand J Haematol. 1979 Apr 4;22(4):289-95. doi: 10.1111/j.1600-0609.1979.tb00422.x.
Erythropoiesis was evaluated in 37 patients with sickle cell anaemia, 26 of them children under 12 years of age. Mean haemoglobin, haematocrit, reticulocyte, and erythropoietin levels were similar for 11 who were asymptomatic, 11 with infections, and 12 in vaso-occlusive crisis. Mean haemoglobin, haematocrit, and reticulocyte values were significantly lower and the mean erythropoietin level significantly higher for three patients in aplastic crisis. Reticulocyte counts reflected erythropoietic activity during the asymptomatic state but were variable during infection and crisis. No erythropoietic inhibitory activity was found in any of the four clinical states. It has been suggested that erythropoietin production decreases during infection. Patients in this study responded appropriately to stress, showing no decrease in erythropoietic activity during acute infection or crisis.
对37例镰状细胞贫血患者的红细胞生成情况进行了评估，其中26例为12岁以下儿童。11例无症状患者、11例感染患者和12例血管闭塞性危象患者的平均血红蛋白、血细胞比容、网织红细胞和促红细胞生成素水平相似。再生障碍性危象的3例患者平均血红蛋白、血细胞比容和网织红细胞值显著降低，平均促红细胞生成素水平显著升高。网织红细胞计数反映了无症状状态下的红细胞生成活性，但在感染和危象期间有所变化。在这四种临床状态中均未发现红细胞生成抑制活性。有人认为感染期间促红细胞生成素的产生会减少。本研究中的患者对压力反应适当，在急性感染或危象期间红细胞生成活性未降低。
