镰状细胞病中的促红细胞生成素与肾功能
Erythropoietin and renal function in sickle-cell disease.
作者信息
Morgan A G, Gruber C A, Serjeant G R
出版信息
Br Med J (Clin Res Ed). 1982 Dec 11;285(6356):1686-8. doi: 10.1136/bmj.285.6356.1686.
Abstract
The relation between haemoglobin concentration, creatinine clearance, and the serum concentration of erythropoiesis-stimulating factor were assessed in 31 patients with homozygous sickle-cell disease. Haemoglobin concentrations fell significantly with decreasing creatinine clearance (r = 0.58, p less than 0.001) and were positively correlated with the concentration of erythropoiesis-stimulating factor (r = 0.65, p less than 0.001). These observations suggest that erythropoietin concentration is the factor limiting production of red cells in sickle-cell disease with renal insufficiency and have implications for treatment.
摘要
对31例纯合子镰状细胞病患者的血红蛋白浓度、肌酐清除率和促红细胞生成因子的血清浓度之间的关系进行了评估。血红蛋白浓度随肌酐清除率降低而显著下降（r = 0.58，p < 0.001），且与促红细胞生成因子浓度呈正相关（r = 0.65，p < 0.001）。这些观察结果表明，促红细胞生成素浓度是肾功能不全的镰状细胞病中限制红细胞生成的因素，并且对治疗具有启示意义。
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