碘-125标记的雌二醇：一种与雌激素受体结合的发射γ射线的雌二醇类似物。
Iodine-125--labeled estradiol: a gamma-emitting analog of estradiol that binds to the estrogen receptor.
作者信息
Hochberg R B
出版信息
Science. 1979 Sep 14;205(4411):1138-40. doi: 10.1126/science.472733.
PMID:472733
Abstract
17 beta-[16 alpha-125I]Iodoestradiol has been synthesized by exchange of 16 beta-bromoestradiol with Na125I. The iodinated product is readily separated from the bromo reactant by column chromatography. It concentrates in the rat uterus in vivo and binds avidly and specifically to the uterine estrogen receptor in vitro.
摘要
17β-[16α-125I]碘雌二醇是通过16β-溴雌二醇与Na125I进行交换反应合成的。碘化产物可通过柱色谱法轻松地与溴化反应物分离。它在体内可浓集于大鼠子宫，在体外能与子宫雌激素受体发生强烈且特异性的结合。
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