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Imbalance in X-chromosome expression: evidence for a human X-linked gene affecting growth of hemopoietic cells.

作者信息

Luzzatto L, Usanga E A, Bienzle U, Esan G F, Fusuan F A

出版信息

Science. 1979 Sep 28;205(4413):1418-20. doi: 10.1126/science.472761.

DOI:10.1126/science.472761
PMID:472761
Abstract

In each of six family members who were heterozygous at the X-linked locus for glucose-6-phosphate dehydrogenase, only one or the other of the two alleles at that locus was almost exclusively expressed. The data are consistent with evidence that X-chromosome inactivation is a random process that may be followed by selection for one of the two resulting cell types on the basis of an unknown gene, which is located on the X chromosome and which can affect the rate of proliferation of hemopoietic cells in humans.

摘要

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Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):3862-6. doi: 10.1073/pnas.95.7.3862.
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