Ferraris A M, Broccia G, Meloni T, Forteleoni G, Gaetani G F
Division of Hematology, University of Genova, Italy.
Am J Hum Genet. 1988 Mar;42(3):516-20.
We have evaluated the hypothesis of a negative association between glucose 6-phosphate dehydrogenase (G6PD) deficiency and cancer in a cohort of 481 Sardinian males with hematological malignancies. The frequency of G6PD deficiency in the patients was not different from the incidence in a group of 16,219 controls. The same conclusion resulted from the comparison of the frequency of expression of the GdB gene in 23 heterozygous women having a clonal hematologic disease and a control group of 37 healthy heterozygotes. Therefore at present there is no evidence that G6PD deficiency has a protective effect against development of hematologic neoplasms.
我们在一个由481名患有血液系统恶性肿瘤的撒丁岛男性组成的队列中，评估了葡萄糖-6-磷酸脱氢酶（G6PD）缺乏与癌症之间存在负相关的假设。患者中G6PD缺乏的频率与一组16219名对照者的发病率没有差异。对23名患有克隆性血液病的杂合子女性和37名健康杂合子对照组中GdB基因表达频率的比较也得出了相同的结论。因此，目前没有证据表明G6PD缺乏对血液系统肿瘤的发生具有保护作用。
