葡萄糖-6-磷酸脱氢酶缺乏症与血液系统恶性肿瘤的发病率
Glucose 6-phosphate dehydrogenase deficiency and incidence of hematologic malignancy.
作者信息
Ferraris A M, Broccia G, Meloni T, Forteleoni G, Gaetani G F
机构信息
Division of Hematology, University of Genova, Italy.
出版信息
Am J Hum Genet. 1988 Mar;42(3):516-20.
Abstract
We have evaluated the hypothesis of a negative association between glucose 6-phosphate dehydrogenase (G6PD) deficiency and cancer in a cohort of 481 Sardinian males with hematological malignancies. The frequency of G6PD deficiency in the patients was not different from the incidence in a group of 16,219 controls. The same conclusion resulted from the comparison of the frequency of expression of the GdB gene in 23 heterozygous women having a clonal hematologic disease and a control group of 37 healthy heterozygotes. Therefore at present there is no evidence that G6PD deficiency has a protective effect against development of hematologic neoplasms.
摘要
我们在一个由481名患有血液系统恶性肿瘤的撒丁岛男性组成的队列中，评估了葡萄糖-6-磷酸脱氢酶（G6PD）缺乏与癌症之间存在负相关的假设。患者中G6PD缺乏的频率与一组16219名对照者的发病率没有差异。对23名患有克隆性血液病的杂合子女性和37名健康杂合子对照组中GdB基因表达频率的比较也得出了相同的结论。因此，目前没有证据表明G6PD缺乏对血液系统肿瘤的发生具有保护作用。
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本文引用的文献
1
2-deoxy-glucose-6-phosphate utilization in the study of glucose-6-phosphate dehydrogenase mosaicism.
Am J Hum Genet. 1981 Mar;33(2):307-13.
2
3
Clonal origin of cells restricted to monocytic differentiation in acute nonlymphocytic leukemia.
Blood. 1984 Oct;64(4):817-20.
4
Reexpression of normal stem cells in erythroleukemia during remission.
Blood. 1983 Jul;62(1):177-9.
5
Immunoglobulin-gene rearrangements as unique clonal markers in human lymphoid neoplasms.
N Engl J Med. 1983 Dec 29;309(26):1593-9. doi: 10.1056/NEJM198312293092601.
6
Glucose-6-phosphate dehydrogenase deficiency in Italy. A study of the distribution and severity of the enzymatic defect.
Acta Haematol. 1969;41(6):331-40. doi: 10.1159/000208870.
7
G.-6-P.D. deficiency and cancer.
Lancet. 1970 May 16;1(7655):1060-1. doi: 10.1016/s0140-6736(70)91195-5.
8
G.-6-P.D. deficiency and cancer.
Lancet. 1972 May 27;1(7761):1185. doi: 10.1016/s0140-6736(72)91416-x.
9
Clonal development from a progenitor with restricted differentiative expression in acute lymphoblastic leukemia.
Am J Hematol. 1985 Sep;20(1):81-3. doi: 10.1002/ajh.2830200111.
10
Variability of red cell phenotypes between and within individuals in an unbiased sample of 77 heterozygotes for G6PD deficiency in Sardinia.
Am J Hum Genet. 1976 Sep;28(5):496-505.
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