葡萄糖-6-磷酸脱氢酶缺乏症与血液系统恶性肿瘤的发病率
Glucose 6-phosphate dehydrogenase deficiency and incidence of hematologic malignancy.
作者信息
Ferraris A M, Broccia G, Meloni T, Forteleoni G, Gaetani G F
机构信息
Division of Hematology, University of Genova, Italy.
出版信息
Am J Hum Genet. 1988 Mar;42(3):516-20.
Abstract
We have evaluated the hypothesis of a negative association between glucose 6-phosphate dehydrogenase (G6PD) deficiency and cancer in a cohort of 481 Sardinian males with hematological malignancies. The frequency of G6PD deficiency in the patients was not different from the incidence in a group of 16,219 controls. The same conclusion resulted from the comparison of the frequency of expression of the GdB gene in 23 heterozygous women having a clonal hematologic disease and a control group of 37 healthy heterozygotes. Therefore at present there is no evidence that G6PD deficiency has a protective effect against development of hematologic neoplasms.
摘要
我们在一个由481名患有血液系统恶性肿瘤的撒丁岛男性组成的队列中，评估了葡萄糖-6-磷酸脱氢酶（G6PD）缺乏与癌症之间存在负相关的假设。患者中G6PD缺乏的频率与一组16219名对照者的发病率没有差异。对23名患有克隆性血液病的杂合子女性和37名健康杂合子对照组中GdB基因表达频率的比较也得出了相同的结论。因此，目前没有证据表明G6PD缺乏对血液系统肿瘤的发生具有保护作用。
相似文献
1
Glucose 6-phosphate dehydrogenase deficiency and incidence of hematologic malignancy.葡萄糖-6-磷酸脱氢酶缺乏症与血液系统恶性肿瘤的发病率
Am J Hum Genet. 1988 Mar;42(3):516-20.
2
Effect of age, period and birth-cohort on the frequency of glucose-6-phosphate dehydrogenase deficiency in Sardinian adults.年龄、时期和出生队列对撒丁岛成年人葡萄糖-6-磷酸脱氢酶缺乏症频率的影响。
Ann Med. 2018 Feb;50(1):68-73. doi: 10.1080/07853890.2017.1390247. Epub 2017 Oct 16.
3
Identification of glucose 6-phosphate dehydrogenase deficiency in a population with a high frequency of thalassemia.在地中海贫血高发人群中鉴定葡萄糖-6-磷酸脱氢酶缺乏症
FEBS Lett. 2000 Jan 21;466(1):139-42. doi: 10.1016/s0014-5793(99)01776-7.
4
DNA hypermethylation and X chromosome inactivation are major determinants of phenotypic variation in women heterozygous for G6PD mutations.DNA高甲基化和X染色体失活是葡萄糖-6-磷酸脱氢酶（G6PD）突变杂合女性表型变异的主要决定因素。
Blood Cells Mol Dis. 2014 Dec;53(4):241-5. doi: 10.1016/j.bcmd.2014.06.001. Epub 2014 Jun 21.
5
Heterozygous pyruvate kinase deficiency and severe hemolytic anemia in a pregnant woman with concomitant, glucose-6-phosphate dehydrogenase deficiency.一名患有葡萄糖-6-磷酸脱氢酶缺乏症的孕妇，同时存在杂合子丙酮酸激酶缺乏症和严重溶血性贫血。
Ann Hematol. 1991 May;62(5):190-3. doi: 10.1007/BF01703148.
6
Newborn screening of glucose-6-phosphate dehydrogenase deficiency in Guangxi, China: determination of optimal cutoff value to identify heterozygous female neonates.中国广西葡萄糖-6-磷酸脱氢酶缺乏症的新生儿筛查：确定最佳截断值以识别杂合子女性新生儿。
Sci Rep. 2018 Jan 16;8(1):833. doi: 10.1038/s41598-017-17667-6.
7
Association of glucose-6-phosphate dehydrogenase deficiency and malaria: a systematic review and meta-analysis.葡萄糖-6-磷酸脱氢酶缺乏与疟疾的关系：系统评价和荟萃分析。
Sci Rep. 2017 Apr 6;7:45963. doi: 10.1038/srep45963.
8
Frequency of glucose-6-phosphate dehydrogenase phenotypes and deficiency in Al-Baha.巴哈地区葡萄糖-6-磷酸脱氢酶表型及缺乏症的频率
Hum Hered. 1989;39(6):313-7. doi: 10.1159/000153882.
9
Malaria and erythrocyte glucose-6-phosphate dehydrogenase variants in West Africa.西非的疟疾与红细胞葡萄糖-6-磷酸脱氢酶变体
Am J Trop Med Hyg. 1979 Jul;28(4):619-21.
10
Reduced prevalence of Plasmodium falciparum infection and of concomitant anaemia in pregnant women with heterozygous G6PD deficiency.杂合子葡萄糖-6-磷酸脱氢酶（G6PD）缺乏的孕妇中，恶性疟原虫感染及合并贫血的患病率降低。
Trop Med Int Health. 2003 Feb;8(2):118-24. doi: 10.1046/j.1365-3156.2003.01008.x.
引用本文的文献
1
Assessing glucose 6-phosphate dehydrogenase activity in children with acute lymphoblastic leukemia and its relationship to disease activity.评估急性淋巴细胞白血病患儿的葡萄糖-6-磷酸脱氢酶活性及其与疾病活动的关系。
Am J Blood Res. 2025 Aug 15;15(4):80-89. doi: 10.62347/QFMM6731. eCollection 2025.
2
Glucose-6-phosphate dehydrogenase deficiency and long-term risk of immune-related disorders.葡萄糖-6-磷酸脱氢酶缺乏症与长期免疫相关疾病风险。
Front Immunol. 2023 Sep 11;14:1232560. doi: 10.3389/fimmu.2023.1232560. eCollection 2023.
3
Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency and Long-Term Risk of Immune-Related diseases.葡萄糖-6-磷酸脱氢酶（G6PD）缺乏症与免疫相关疾病的长期风险
medRxiv. 2023 Mar 24:2023.03.23.23287616. doi: 10.1101/2023.03.23.23287616.
4
F-fluoro-2-deoxy-d-glucose (FDG) uptake. What are we looking at?氟代脱氧葡萄糖（FDG）摄取。我们看到的是什么？
Eur J Nucl Med Mol Imaging. 2021 May;48(5):1278-1286. doi: 10.1007/s00259-021-05368-2.
5
Two high-rate pentose-phosphate pathways in cancer cells.癌细胞中有两条高活性戊糖磷酸途径。
Sci Rep. 2020 Dec 17;10(1):22111. doi: 10.1038/s41598-020-79185-2.
6
Inhibiting both proline biosynthesis and lipogenesis synergistically suppresses tumor growth.同时抑制脯氨酸生物合成和脂肪生成可协同抑制肿瘤生长。
J Exp Med. 2020 Mar 2;217(3). doi: 10.1084/jem.20191226.
7
Glucose-6-phosphate dehydrogenase deficiency and risk of colorectal cancer in Northern Sardinia: A retrospective observational study.撒丁岛北部葡萄糖-6-磷酸脱氢酶缺乏症与结直肠癌风险：一项回顾性观察研究。
Medicine (Baltimore). 2016 Nov;95(44):e5254. doi: 10.1097/MD.0000000000005254.
8
Metabolic reprogramming: a cancer hallmark even warburg did not anticipate.代谢重编程：癌症的一个标志，甚至连沃伯格都没有预料到。
Cancer Cell. 2012 Mar 20;21(3):297-308. doi: 10.1016/j.ccr.2012.02.014.
9
A new glucose-6-phosphate dehydrogenase variant with congenital nonspherocytic hemolytic anemia (G6PD Genova). Biochemical characterization and mosaicism expression in the heterozygote.一种伴有先天性非球形红细胞溶血性贫血的新型葡萄糖-6-磷酸脱氢酶变异体（G6PD热那亚型）。杂合子中的生化特征及嵌合体表达
Hum Genet. 1990 Mar;84(4):337-40. doi: 10.1007/BF00196229.
本文引用的文献
1
2-deoxy-glucose-6-phosphate utilization in the study of glucose-6-phosphate dehydrogenase mosaicism.2-脱氧葡萄糖-6-磷酸在6-磷酸葡萄糖脱氢酶嵌合体研究中的应用。
Am J Hum Genet. 1981 Mar;33(2):307-13.
2
3
Clonal origin of cells restricted to monocytic differentiation in acute nonlymphocytic leukemia.
Blood. 1984 Oct;64(4):817-20.
4
Reexpression of normal stem cells in erythroleukemia during remission.缓解期红白血病中正常干细胞的重新表达。
Blood. 1983 Jul;62(1):177-9.
5
Immunoglobulin-gene rearrangements as unique clonal markers in human lymphoid neoplasms.免疫球蛋白基因重排作为人类淋巴肿瘤中独特的克隆标志物。
N Engl J Med. 1983 Dec 29;309(26):1593-9. doi: 10.1056/NEJM198312293092601.
6
Glucose-6-phosphate dehydrogenase deficiency in Italy. A study of the distribution and severity of the enzymatic defect.
Acta Haematol. 1969;41(6):331-40. doi: 10.1159/000208870.
7
G.-6-P.D. deficiency and cancer.
Lancet. 1970 May 16;1(7655):1060-1. doi: 10.1016/s0140-6736(70)91195-5.
8
G.-6-P.D. deficiency and cancer.
Lancet. 1972 May 27;1(7761):1185. doi: 10.1016/s0140-6736(72)91416-x.
9
Clonal development from a progenitor with restricted differentiative expression in acute lymphoblastic leukemia.
Am J Hematol. 1985 Sep;20(1):81-3. doi: 10.1002/ajh.2830200111.
Zotero 插件