人胆汁酸组成的性别差异：对有和没有胆结石患者的研究。
Sex differences in the bile acid composition of human bile: studies in patients with and without gallstones.
作者信息
Fisher M M, Yousef I M
出版信息
Can Med Assoc J. 1973 Aug 4;109(3):190-3.
Abstract
The bile acid composition of human gallbladder bile was studied in 83 subjects, 20 of each sex without discernible hepatobiliary disease, and 20 men and 23 women with cholelithiasis. The bile acids were measured by combined thin-layer and gas-liquid chromatography.In the bile of patients without cholelithiasis the molar percent of cholic acid was significantly greater in men while that of chenodeoxycholic acid was significantly greater in women.In the bile of patients with cholelithiasis the concentration of total bile acids was reduced in both sexes but there was no sex difference in the molar percent of any of the bile acids. The molar percent of CDCA (both glycine and taurine conjugates) was reduced in women, while the molar percent of CA (only the glycine conjugate) was reduced in men.
摘要
对83名受试者的人胆囊胆汁酸组成进行了研究，其中20名男性和20名女性无明显肝胆疾病，另有20名男性和23名女性患有胆结石。通过薄层色谱和气相色谱联用测定胆汁酸。在无胆结石患者的胆汁中，男性胆酸的摩尔百分比显著更高，而鹅去氧胆酸在女性中显著更高。在胆结石患者的胆汁中，两性的总胆汁酸浓度均降低，但任何一种胆汁酸的摩尔百分比均无性别差异。女性中CDCA（甘氨酸和牛磺酸共轭物）的摩尔百分比降低，而男性中CA（仅甘氨酸共轭物）的摩尔百分比降低。
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