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1-氮杂环丁烷-2-羧酸对四氯化碳处理大鼠肝纤维化的抑制作用

Inhibition of liver fibrosis by 1-azetidine-2-carboxylic acid in rats treated with carbon tetrachloride.

作者信息

Rojkind M

出版信息

J Clin Invest. 1973 Oct;52(10):2451-6. doi: 10.1172/JCI107436.

DOI:10.1172/JCI107436
PMID:4729042
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC302504/
Abstract

L-Azetidine-2-carboxylic acid (AZC), an analogue of proline, has been shown to partially ameliorate hepatic cirrhosis induced in rats by CCl(4). AZC caused a diminution in formation of collagen in the liver accompanied by a relative decrease in the pool of free proline. The synthesis of noncollagenous proteins in the livers of treated rats did not appear to be affected.

摘要

L-氮杂环丁烷-2-羧酸（AZC）是脯氨酸的类似物，已被证明可部分改善四氯化碳诱导的大鼠肝硬化。AZC导致肝脏中胶原蛋白形成减少，同时游离脯氨酸池相对减少。经处理的大鼠肝脏中非胶原蛋白的合成似乎未受影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1761/302504/859a7070ef94/jcinvest00185-0075-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1761/302504/859a7070ef94/jcinvest00185-0075-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1761/302504/859a7070ef94/jcinvest00185-0075-a.jpg

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Inhibition of liver fibrosis by 1-azetidine-2-carboxylic acid in rats treated with carbon tetrachloride.1-氮杂环丁烷-2-羧酸对四氯化碳处理大鼠肝纤维化的抑制作用
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引用本文的文献

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Antifibrotic effect of a proline analogue delivered in liposomes to cells in culture.脂质体递送至培养细胞中脯氨酸类似物的抗纤维化作用。
Amino Acids. 1993 Oct;4(3):237-48. doi: 10.1007/BF00805825.
2
Propolis prevents hepatorenal injury induced by chronic exposure to carbon tetrachloride.蜂胶可预防四氯化碳慢性暴露引起的肝肾损伤。
Evid Based Complement Alternat Med. 2012;2012:235358. doi: 10.1155/2012/235358. Epub 2011 Aug 4.
3
Connective tissue components of the normal and fibrotic human liver. II. Clinical aspects.正常及纤维化人类肝脏的结缔组织成分。II. 临床方面。

本文引用的文献

1
A method for the simultaneous measurement of the radioactivity of proline-C14 and hydroxyproline-C14 in biological materials.一种同时测量生物材料中脯氨酸 - C14和羟脯氨酸 - C14放射性的方法。
Anal Biochem. 1962 Nov;4:400-6. doi: 10.1016/0003-2697(62)90141-0.
2
The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acid.对含有少量这种亚氨基酸的组织和蛋白质样品中羟脯氨酸的测定。
Arch Biochem Biophys. 1961 May;93:440-7. doi: 10.1016/0003-9861(61)90291-0.
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A photometric method for the determination of proline.
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Regional brain GABA metabolism and release during hepatic coma produced in rats chronically treated with carbon tetrachloride.四氯化碳长期处理的大鼠发生肝昏迷时脑内区域γ-氨基丁酸代谢及释放情况
Neurochem Res. 1988 Jan;13(1):37-44. doi: 10.1007/BF00971852.
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Liver collagen synthesis in murine schistosomiasis.小鼠血吸虫病中的肝脏胶原蛋白合成
J Clin Invest. 1977 Apr;59(4):666-74. doi: 10.1172/JCI108685.
6
Collagen metabolism in the liver. An annotated and supplemented report of a workshop at the National Institutes of Health on February 28 and March 1, 1977.肝脏中的胶原蛋白代谢。1977年2月28日和3月1日在美国国立卫生研究院举办的一次研讨会的注释及补充报告。
Am J Dig Dis. 1978 Jul;23(7):641-59.
一种测定脯氨酸的光度法。
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Amino acid transport in bone. II. Regulation of collagen synthesis by perturbation of proline transport.骨骼中的氨基酸转运。II. 脯氨酸转运扰动对胶原蛋白合成的调节。
Biochim Biophys Acta. 1967;135(5):1008-15. doi: 10.1016/0005-2736(67)90071-5.
5
Amino acid transport in bone. Evidence for separate transport systems for neutral amino and imino acids.骨骼中的氨基酸转运。中性氨基酸和亚氨基酸存在独立转运系统的证据。
J Biol Chem. 1966 Apr 10;241(7):1487-93.
6
Collagen biosynthesis in normal and cirrhotic rat liver slices.正常和肝硬化大鼠肝切片中的胶原蛋白生物合成
Proc Soc Exp Biol Med. 1969 May;131(1):200-3. doi: 10.3181/00379727-131-33839.
7
Biosynthesis of abnormal collagens with amino acid analogues. II. Inability of cartilage cells to extrude collagen polypeptides containing L-azetidine-2-carboxylic acid or cis-4-fluoro-L-proline.用氨基酸类似物进行异常胶原蛋白的生物合成。II. 软骨细胞无法排出含有L-氮杂环丁烷-2-羧酸或顺式-4-氟-L-脯氨酸的胶原蛋白多肽。
Biochim Biophys Acta. 1969 Feb 4;175(1):156-64.
8
Effect of the proline analogue azetidine-2-carboxylic acid on collagen synthesis in vivo. I. Arrest of collagen accumulation in growing chick embryos.脯氨酸类似物氮杂环丁烷-2-羧酸对体内胶原蛋白合成的影响。I. 生长中的鸡胚胶原蛋白积累的停滞
Biochim Biophys Acta. 1971 Jun 29;236(3):517-27. doi: 10.1016/0005-2795(71)90235-2.
9
Compartmental analysis of collagen synthesis in fetal rat calvaria. I. Perturbations of proline transport.胎鼠颅骨胶原合成的区室分析。I. 脯氨酸转运的扰动
Biochim Biophys Acta. 1971 Jan 26;230(1):146-59. doi: 10.1016/0304-4165(71)90062-6.
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The relationship between the free pool of proline and collagen content in human liver cirrhosis.人类肝硬化中脯氨酸游离池与胶原蛋白含量之间的关系。
J Clin Invest. 1970 Dec;49(12):2246-9. doi: 10.1172/JCI106443.