Kaplan C G, Askin F B, Benirschke K
Teratology. 1979 Apr;19(2):261-6. doi: 10.1002/tera.1420190217.
Tissue from six human extragonadal teratomas was obtained for cytogenetic study. These included two gluteal lesions in infant females, and one each of thyroid, mediastinal, sacral and gastric teratomas in males. Tissue culture characteristics indicated tumor growth. All tumors, except the mediastinal lesion showed the presumed karyotype of its host, XX or XY. The mediastinal mass was tetraploid XXYY and contained an X chromatin body and double Y bodies. Our data support the concept that extragonadal teratomas in males and females arise mitotically from diploid cells and are more similar to identical twins. No heterosexual (XX) tumors were seen in males which would be expected in parthenogenetic tumors. The sex chromatin positive tumors seen in earlier studies may have resulted from polyploidy. Thus, male and female extragonadal teratomas have a different origin from the postmeiotic ovarian teratomas.
获取了来自六例人体性腺外畸胎瘤的组织用于细胞遗传学研究。其中包括两例婴儿女性臀部病变，以及男性的甲状腺、纵隔、骶尾部和胃部畸胎瘤各一例。组织培养特征显示有肿瘤生长。除纵隔病变外，所有肿瘤均显示出其宿主推测的核型，即XX或XY。纵隔肿块为四倍体XXYY，含有一个X染色质体和两个Y体。我们的数据支持这样的概念，即男性和女性的性腺外畸胎瘤由二倍体细胞有丝分裂产生，并且更类似于同卵双胞胎。在男性中未见到预期在孤雌生殖肿瘤中出现的异性（XX）肿瘤。早期研究中所见的性染色质阳性肿瘤可能是由多倍体导致的。因此，男性和女性的性腺外畸胎瘤与减数分裂后的卵巢畸胎瘤起源不同。
