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小脑齿状核中浦肯野细胞轴突终末部分的病理变化。

Pathological changes in the terminal parts of Purkynĕ cell axons in the dentate nucleus of the cerebellum.

作者信息

Janota I

出版信息

J Neurol Neurosurg Psychiatry. 1973 Aug;36(4):596-603. doi: 10.1136/jnnp.36.4.596.

DOI:10.1136/jnnp.36.4.596
PMID:4731329
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC494415/
Abstract

This paper describes abnormal argyrophilic swellings and rings in the dentate nucleus of the cerebellum in 46 cases of various human pathological conditions. The swellings represent accumulations of neurofilaments in the terminal parts of Purkyně cell axons. They may be evidence of disturbed functions of the Purkyně cell terminals due to different causes and common to many pathological conditions. These are as varied as acute ischaemic cerebellar cortical lesions, liver failure, and chronic nervous system degenerations, such as progressive supranuclear palsy and Friedreich's ataxia, and include transmissible ones like Creutzfeldt-Jakob disease.

摘要

本文描述了46例患有各种人类病理状况的患者小脑齿状核中异常嗜银性肿胀和环。这些肿胀代表浦肯野细胞轴突末端神经丝的积聚。它们可能是由于不同原因导致的浦肯野细胞终末功能紊乱的证据，且在许多病理状况中都很常见。这些病理状况多种多样，包括急性缺血性小脑皮质病变、肝功能衰竭以及慢性神经系统退行性疾病，如进行性核上性麻痹和弗里德赖希共济失调，还包括可传播的疾病，如克雅氏病。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a1a/494415/f20bb88e2885/jnnpsyc00202-0104-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a1a/494415/2a2c7c22cee8/jnnpsyc00202-0103-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a1a/494415/bf8430e08738/jnnpsyc00202-0103-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a1a/494415/55ba57a86785/jnnpsyc00202-0103-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a1a/494415/8f93252ec06f/jnnpsyc00202-0104-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a1a/494415/f20bb88e2885/jnnpsyc00202-0104-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a1a/494415/2a2c7c22cee8/jnnpsyc00202-0103-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a1a/494415/bf8430e08738/jnnpsyc00202-0103-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a1a/494415/55ba57a86785/jnnpsyc00202-0103-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a1a/494415/8f93252ec06f/jnnpsyc00202-0104-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a1a/494415/f20bb88e2885/jnnpsyc00202-0104-b.jpg

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引用本文的文献

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Pathology of the dentate nucleus in progressive supranuclear palsy: a histological, immunohistochemical and ultrastructural study.进行性核上性麻痹中齿状核的病理学：一项组织学、免疫组织化学及超微结构研究
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2
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Virchows Arch A Pathol Anat Histol. 1978 Jun 15;378(3):181-97. doi: 10.1007/BF00427359.

本文引用的文献

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Electron microscopy of experimental degeneration in the avian optic tectum.鸟类视顶盖实验性退变的电子显微镜观察
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SOME ELECTRON MICROSCOPICAL OBSERVATIONS OF DEGENERATIVE CHANGES IN CENTRAL NERVOUS SYNAPSES.中枢神经突触退变变化的一些电子显微镜观察
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Distinction of degenerating fibres and boutons of cerebellar and peripheral origin in the deiters' nucleus of the same animal.同一动物的Deiters核中来自小脑和外周的变性纤维与终扣的区分。
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