弥散性血管内凝血在犬类输血所致休克中的作用。

The role of disseminated intravascular coagulation in shock induced by transfusion of human blood in dogs.

作者信息

Takaki A, Kato H, Takeda S, Kishikawa H, Torisu M, Ohsato K

出版信息

Transfusion. 1979 Jul-Aug;19(4):404-10. doi: 10.1046/j.1537-2995.1979.19479250177.x.

DOI:10.1046/j.1537-2995.1979.19479250177.x

Abstract

Hemolytic blood transfusion reactions were produced in 20 dogs. Animals transfused with human blood twice in a two-week interval demonstrated a significant increase in anti-human red blood cell agglutination titer at the time of the second transfusion. Eighteen dogs that survived from the first transfusion reaction were divided into two groups with or without heparin treatment. The hemolytic transfusion reaction in the sensitized animals was characterized by shock and multiple coagulation abnormalities. Heparin failed to prevent shock, hemoglobinemia and thrombocytopenia, and decreased the mortality rate in heparinized animals. Pathologic examination revealed that the thrombi in the splanchnic organs were less common in the heparinized dogs.

摘要

在20只犬身上引发了溶血性输血反应。在两周内接受两次人血输血的动物，在第二次输血时抗人红细胞凝集效价显著升高。18只在第一次输血反应中存活下来的犬被分为两组，一组接受肝素治疗，另一组未接受。致敏动物的溶血性输血反应表现为休克和多种凝血异常。肝素未能预防休克、血红蛋白血症和血小板减少症，但降低了接受肝素治疗动物的死亡率。病理检查显示，肝素化犬内脏器官中的血栓较少见。