左旋多巴对清醒家兔血压的作用。
Actions of levodopa on the blood pressure of conscious rabbits.
作者信息
Calne D B, Reid J L
出版信息
Br J Pharmacol. 1973 Jun;48(2):194-7. doi: 10.1111/j.1476-5381.1973.tb06905.x.
Abstract
- In conscious rabbits, the rapid intravenous injection of levodopa alone does not have any significant effects on the blood pressure in doses up to 10 mg/kg.2. After inhibition of monoamine oxidase, levodopa induces a sustained pressor response.3. This response can be blocked by inhibition of extracerebral decarboxylase.4. Possible mechanisms for these interactions are discussed, together with their therapeutic implications in Parkinsonism.
摘要
在清醒的兔子中，静脉快速注射单独的左旋多巴，剂量高达10毫克/千克时对血压没有任何显著影响。
抑制单胺氧化酶后，左旋多巴会引发持续的升压反应。
这种反应可通过抑制脑外脱羧酶来阻断。
讨论了这些相互作用的可能机制，以及它们在帕金森病中的治疗意义。
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Actions of levodopa on the blood pressure of conscious rabbits.左旋多巴对清醒家兔血压的作用。
Br J Pharmacol. 1973 Jun;48(2):194-7. doi: 10.1111/j.1476-5381.1973.tb06905.x.
2
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引用本文的文献
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Monoamine oxidase and cerebral uptake of dopaminergic drugs.单胺氧化酶与多巴胺能药物的脑摄取
Proc Natl Acad Sci U S A. 1974 Jul;71(7):2715-9. doi: 10.1073/pnas.71.7.2715.
本文引用的文献
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The cardiovascular pharmacology of L(--)-dopa: peripheral and central effects.左旋多巴的心血管药理学：外周和中枢作用
J Pharmacol Exp Ther. 1971 Sep;178(3):517-28.
2
Influence of pargyline on the effects of dopamine infusions on sympathetically innervated tissues.帕吉林对多巴胺输注对交感神经支配组织的影响
Neuropharmacology. 1970 Sep;9(5):457-65. doi: 10.1016/0028-3908(70)90019-5.
3
New evidence for an -andrenergic component in the sympathetic centres: centrally mediated decrease in sympathetic tone by L-dopa and its antagonism by piperoxane and yohimbine.交感神经中枢中α-肾上腺素能成分的新证据：左旋多巴对交感神经张力的中枢介导性降低及其被哌罗克生和育亨宾拮抗的作用
Eur J Pharmacol. 1972 Feb;17(2):293-6. doi: 10.1016/0014-2999(72)90173-2.
4
Cardiovascular and renal actions of dopamine: potential clinical applications.多巴胺的心血管和肾脏作用：潜在的临床应用
Pharmacol Rev. 1972 Mar;24(1):1-29.
5
Effects of dopamine on the conductance of perfused vascular beds of the chloralosed cat.多巴胺对水合氯醛麻醉猫灌注血管床传导性的影响。
Br J Pharmacol. 1972 Mar;44(3):442-50. doi: 10.1111/j.1476-5381.1972.tb07282.x.
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Evidence for a centrally mediated hypotensive effect of L-dopa in the rat.左旋多巴对大鼠具有中枢介导的降压作用的证据。
J Pharm Pharmacol. 1970 Mar;22(3):241-3. doi: 10.1111/j.2042-7158.1970.tb08510.x.
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Modification of the cardiovascular effects of L-dopa in anesthetized dogs by inhibitors of enzymes involved in catecholamine metabolism.
Circ Res. 1971 Jun;28(6):662-70. doi: 10.1161/01.res.28.6.662.
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