冷冻宁对大鼠足跖热肿胀及大鼠离体子宫的作用评估。
Evaluation of cryogenine on rat paw thermal oedema and rat isolated uterus.
作者信息
Malone M H, Trottier R W
出版信息
Br J Pharmacol. 1973 Jun;48(2):255-62. doi: 10.1111/j.1476-5381.1973.tb06911.x.
Abstract
- Significant inhibition of oedema formation caused by thermal injury was observed for calcium carbaspirin, phenylbutazone, hydrocortisone, cryogenine and indomethacin when given daily beginning 2 days prior to thermal exposure and afterwards. Several anti-inflammatory drugs, including cryogenine, failed to reduce thermal oedema significantly when given as single doses 1 h prior to the thermal injury.2. Kinetic experiments on the rat isolated uterus demonstrated that cryogenine, chlorpromazine, and flufenamic acid were, in part, competitive inhibitors of synthetic bradykinin, while indomethacin and tetrabenazine showed only non-competitive antagonism.
摘要
观察到，从热暴露前两天开始每日给予卡巴匹林钙、保泰松、氢化可的松、克冠二氮卓和吲哚美辛，可显著抑制热损伤引起的水肿形成。包括克冠二氮卓在内的几种抗炎药，在热损伤前1小时单剂量给药时，未能显著减轻热水肿。
对大鼠离体子宫的动力学实验表明，克冠二氮卓、氯丙嗪和氟芬那酸部分是合成缓激肽的竞争性抑制剂，而吲哚美辛和丁苯那嗪仅表现出非竞争性拮抗作用。
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本文引用的文献
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Antagonism by mefenamic and flufenamic acids of the bronchoconstrictor action of kinins in the guinea-pig.甲灭酸和氟灭酸对豚鼠体内激肽支气管收缩作用的拮抗作用
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Release of bradykinin and the mechanism of production of a "thermic edema (45 degrees C)" in the rat's paw.大鼠爪中缓激肽的释放及“热水肿（45摄氏度）”的产生机制。
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Anti-inflammatory evaluation of cryogenine.青藤碱的抗炎作用评价
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Significance of the kinin system in rat paw oedemas and drug effects on it.激肽系统在大鼠爪部水肿中的意义以及药物对其的影响。
Eur J Pharmacol. 1967 May;1(3):222-5. doi: 10.1016/0014-2999(67)90007-6.
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Bradykinin and oedema formation in heated paws of rats.大鼠受热爪子中的缓激肽与水肿形成
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The influence of analgesic antipyretic drugs on the responses of guinea-pig lungs to bradykinin.解热镇痛药对豚鼠肺脏对缓激肽反应的影响。
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Antagonism by fenamates and like-acting drugs of bronchoconstriction induced by bradykinin or antigen in the guinea-pig.芬那酸盐及类似作用药物对豚鼠中由缓激肽或抗原诱导的支气管收缩的拮抗作用。
Br J Pharmacol. 1968 Sep;34(1):76-87. doi: 10.1111/j.1476-5381.1968.tb07952.x.
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The effect of barbiturate anesthesia and hypothermia on the edema formation caused by subcutaneous injection of 5-hydroxytryptamine in mice.巴比妥类麻醉和低温对小鼠皮下注射5-羟色胺所致水肿形成的影响。
Acta Physiol Scand. 1968 Mar;72(3):378-82. doi: 10.1111/j.1748-1716.1968.tb03860.x.
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Arch Int Pharmacodyn Ther. 1968 May;173(1):44-55.
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